Nov 13, 2019

Immune effects of Lactobacillus casei Shirota in treated HIV-infected patients with poor CD4+ T cell recovery: a randomized trial

AIDS
Simone de Barros TenoreEsper G Kallas

Abstract

HIV infection leads to depletion of intestinal CD4+ T cells, mucosal barrier dysfunction, increased gut permeability and microbial translocation even among patients on suppressive ART. Previous studies suggest probiotics may help restore intestinal function. In this double-blind, placebo-controlled pilot study, we enrolled HIV-infected patients on suppressive ART with poor CD4+ recovery to address the effect of daily oral use of Lactobacillus casei Shirota (LcS) on CD4+ T cell count and CD4/CD8 ratio at 6 and 12 weeks after treatment initiation; immune activation and intestinal microbiome composition were addressed as secondary outcomes. From Jan/2015 to Jul/2016, 48 patients were randomized (1:1) to active intervention or placebo. Groups had comparable demographic and clinical characteristics; only CD4+ T cell nadir was statistically different between groups. All participants were virologically-suppressed under ART. At week 6, the increment in CD4+ T cell count was 17 cells/mm3 (interquartile range [IQR] -33 to 74) in the active intervention arm and 4 cells/mm3 (IQR -43 to 51) in the placebo arm (p = 0.291); at week 12, the change in CD4+ T cell count was 8 cells/mm3 (IQR -30 to 70) in the active arm and 10 cells/mm3 (IQR -50 ...Continue Reading

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Mentioned in this Paper

Biological Markers
Study
CD4 Antigens
Clinical Trials, Randomized
CD4+CD8+
Pilot Projects
Antiretroviral Therapy
HIV Infections
Upper Extremity
Participant

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