Immune enhancement conferred by oral delivery of Lactobacillus rhamnosus HN001 in different milk-based substrates

The Journal of Dairy Research
H S Gill, K J Rutherfurd

Abstract

The probiotic Lactobacillus rhamnosus HN001 is known to enhance immunity in animal models, following oral delivery. In this study, we investigated the immunoenhancing effects of HN001 delivered to mice in different milk-based substrates, including: whole (full-fat) milk supplemented with HN001; fermented milk supplemented with HN001; or whole milk which had been part-fermented by HN001. Direct oral feeding of mice with HN001 in whole milk was shown to enhance the phagocytic activity of blood and peritoneal cells. Similar effects on phagocytosis were observed when UN001 was offered to mice in the form of a milk- or fermented milk-based diet. The degree of immune enhancement conferred by HN001 was similar whether the probiotic was used as an additive or as a fermentative agent. These studies confirm that Lb. rhamnosus HN001, derived originally from dairy food, enhances immune function following oral delivery in different milk bases.

Citations

Jan 1, 2010·Annual Review of Food Science and Technology·Mary Ellen Sanders, Maria L Marco
Jul 14, 2010·FEMS Microbiology Letters·Rachel C AndersonNicole C Roy
Jan 30, 2004·The American Journal of Clinical Nutrition·Jose M SaavedraRobert H Yolken
Mar 18, 2005·Journal of Food Protection·Jong-Hwan ParkJae-Hak Park

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