Immune Escape Mechanisms are Plasmodium's Secret Weapons Foiling the Success of Potent and Persistently Efficacious Malaria Vaccines

Clinical Immunology : the Official Journal of the Clinical Immunology Society
Fouzia Farooq, Elke S Bergmann-Leitner

Abstract

Despite decades of active research, an efficacious vaccine mediating long-term protection is still not available. This review highlights various mechanisms and the different facets by which the parasites outsmart the immune system. An understanding of how the parasites escape immune recognition and interfere with the induction of a protective immune response that provides sterilizing immunity will be crucial to vaccine design.

References

Jul 1, 1994·Research in Immunology·G E Grau, C Behr
Jul 1, 1994·Immunology Letters·P Druilhe, J L Pérignon
Jan 23, 1998·The Journal of Allergy and Clinical Immunology·J PunnonenJ E de Vries
Apr 18, 1998·Biochimica Et Biophysica Acta·R Ramasamy
Jul 12, 2001·Infection and Immunity·G MargosP J Lachmann
Jul 24, 2001·Clinical Immunology : the Official Journal of the Clinical Immunology Society·J JasonW R Jarvis
Apr 3, 2002·The Journal of Experimental Medicine·Huji XuMichael F Good
Apr 4, 2002·The Journal of Infectious Diseases·Stephen L HoffmanThomas L Richie
May 31, 2002·Trends in Parasitology·Sergio Zambrano-VillaLibrado Ortiz-Ortiz
Jan 2, 2004·Nature Medicine·Hajime HisaedaKoji Yasutomo
Jan 5, 2005·The Journal of Experimental Medicine·Alida CoppiPhotini Sinnis
Feb 16, 2005·International Immunology·Elke S Bergmann-LeitnerGeorge C Tsokos
Aug 30, 2005·Anais Da Academia Brasileira De Ciências·Karin Kirchgatter, Hernando A Del Portillo
Feb 8, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Gordon A AwandareDouglas J Perkins
Mar 17, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Nasim Akhtar AnsariPoonam Salotra
Aug 18, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Elke S Bergmann-LeitnerGeorge C Tsokos
Oct 20, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·John M Ong'echaDouglas J Perkins
Sep 23, 2008·Molecular and Biochemical Parasitology·Laura K ErdmanKevin C Kain
Jan 12, 2010·Human Vaccines·Robin F AndersRaymond S Norton
May 14, 2010·Clinical and Vaccine Immunology : CVI·Stanley A Plotkin
May 18, 2010·International Journal of Cancer. Journal International Du Cancer·Collin JacobsMax Schnurr
Dec 3, 2010·PLoS Pathogens·Robin Stephens, Jean Langhorne
May 25, 2011·Expert Review of Vaccines·Jason A RegulesChristian F Ockenhouse

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Citations

Jul 2, 2016·Biochemical and Biophysical Research Communications·Martha P AlbaManuel E Patarroyo
Jun 4, 2020·Vaccines·Wolfgang W LeitnerElke S Bergmann-Leitner
Feb 6, 2021·Vaccines·José Manuel LozanoJuan Edilberto Rincón

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