PMID: 11922077Apr 2, 2002Paper

Immune function of thyroid stimulating hormone and receptor

Critical Reviews in Immunology
H C Wang, J R Klein

Abstract

Thyroid stimulating hormone (TSH) is a central component of the hypothalamus-pituitary-thyroid axis. Although TSH is known for its important biological effects as a neuroendocrine used to regulate thyroid hormone activity and subsequent metabolic functions, TSH also has been shown to be produced and used by cells ofthe mammalian immune system. Moreover, recent findings have linked the use of TSH by cells of the immune system in humans and mice to a group of monocytic cells and lymphocytes--primarily dendritic cells, macrophages, and subset of naïve peripheral T cells. Other studies have demonstrated the capacity of dendritic cells and monocytes to produce biologically active TSH, thereby pointing to a process of paracrine or autocrine TSH-mediated communication during the earliest stages of an immune response to antigen. In this article, these and other features of TSH immune-endocrine interactions are discussed in the context of an intrinsic TSH immunological pathway. Additionally, a hypothesis is proposed in which TSH produced by cells of the immune system during acute antigen exposure plays a dual role, consisting on the one hand of TSH communication during antigen-driven immune activation while concomitantly serving to regu...Continue Reading

Citations

Apr 3, 2004·Molecular Genetics and Metabolism·Bjarne Knudsen, Nadir R Farid
Dec 19, 2003·Arthritis Research & Therapy·Farideh EskandariEsther M Sternberg
Nov 10, 2009·The Journal of Clinical Endocrinology and Metabolism·Raymond S DouglasTerry J Smith
Apr 30, 2014·Frontiers in Immunology·John R Klein
Dec 2, 2005·Arthritis and Rheumatism·Jing LiRobert W McMurray
Feb 3, 2005·Molecular Psychiatry·A Marques-DeakE Sternberg
Nov 10, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ivan MascanfroniClaudia G Pellizas

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