Immune functional assay for immunosuppressive management in post-transplant malignancy.

Clinical Transplantation
Tadahiro UemuraZakiyah Kadry

Abstract

Immunosuppression management in post-transplant malignancy is challenging because of a lack of objective immunologic assessment tools. The ImmuKnow assay measures the ATP level from CD4 T cells, quantifying cell-mediated immunity and providing an insight into the immune status of transplant recipients. Its potential use in patients with post-transplant de novo malignancy was evaluated. Thirteen adult transplant patients with de novo malignancy were divided into survivors (n = 9) and non-survivors (n = 4) after malignancy treatment. Tacrolimus and the ImmuKnow levels were monitored before, during, and after malignancy treatment. The ImmuKnow level in non-survivors group was significantly lower before and after malignancy treatment compared to survivors group (p = 0.013 and 0.0014 respectively). In survivor group, the ImmuKnow level was significantly decreased during malignancy treatment (p = 0.019) but recovered to the initial level after the treatment. However, in non-survivor group, the ImmuKnow level remained suppressed throughout the observed period despite a reduction in immunosuppressive drug levels. The ImmuKnow assay can be an objective means evaluating immune status of patients with de novo malignancy. The ImmuKnow assa...Continue Reading

References

Nov 25, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Sandy FengDouglas W Hanto
Oct 15, 2005·Transplant Immunology·Adriana ZeeviKareem Abu Elmagd
Jul 22, 2006·Pediatric Transplantation·Paul Grimm
Jan 15, 2008·Clinical Transplantation·Tadahiro UemuraGoran B Klintmalm

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Citations

May 9, 2012·Transplantation Proceedings·H H MoonS-K Lee
Jun 29, 2012·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Emilio RodrigoManuel Arias
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Jan 26, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Katharina HaaseAnnekatrin Coordes

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