Immune gene therapy as a neoadjuvant to surgical excision to control metastatic cancers

Cancer Letters
J CashmanGerald C O'Sullivan

Abstract

We investigated if the range of efficacy of a gene-based immunotherapy of solid tumours against systemic disease could be extended when used as a neoadjuvant to surgery. Hundred percent mice whose subcutaneous tumours were surgically removed 4 days post-electroporation with GM-CSF and B7-1 plasmid were systemically resistance to tumour rechallenge. In mice bearing both subcutaneous and hepatic tumours, neoadjuvant treatment of the primary tumour resulted in significant reduction in, or elimination of, hepatic tumour growth, with a significant increase in survival, indicating that control of the primary tumour by immunotherapy was not a prerequisite for containment of systemic disease.

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Citations

Dec 22, 2010·Genetic Vaccines and Therapy·Sara A CollinsMark Tangney
Aug 7, 2010·Journal of Visualized Experiments : JoVE·Simon RajendranMark Tangney
Jan 15, 2011·Cancer Treatment Reviews·M G BourkeG C O'Sullivan
Mar 30, 2011·Experimental Biology and Medicine·Simon RajendranMark Tangney
Jul 27, 2021·Frontiers in Oncology·Karl-Göran Tranberg

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