Abstract
We investigated if the range of efficacy of a gene-based immunotherapy of solid tumours against systemic disease could be extended when used as a neoadjuvant to surgery. Hundred percent mice whose subcutaneous tumours were surgically removed 4 days post-electroporation with GM-CSF and B7-1 plasmid were systemically resistance to tumour rechallenge. In mice bearing both subcutaneous and hepatic tumours, neoadjuvant treatment of the primary tumour resulted in significant reduction in, or elimination of, hepatic tumour growth, with a significant increase in survival, indicating that control of the primary tumour by immunotherapy was not a prerequisite for containment of systemic disease.
References
Mar 1, 1991·The Journal of Experimental Medicine·P S LinsleyJ A Ledbetter
Feb 1, 1994·The Journal of Experimental Medicine·L ChenK E Hellström
Apr 1, 1994·The Journal of Experimental Medicine·L RamarathinamY Liu
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·G DranoffR C Mulligan
Apr 1, 1996·Cancer·J BrittendenO Eremin
Sep 22, 1998·Nature Biotechnology·H Aihara, J Miyazaki
Apr 21, 1999·Human Gene Therapy·P C EmtageJ Gauldie
Aug 6, 1999·Gene Therapy·Y NasuT C Thompson
Aug 10, 2000·Breast Cancer Research and Treatment·J L MccoyJ A Petros
Mar 20, 2002·Cytokine & Growth Factor Reviews·Ivan Borrello, Drew Pardoll
Aug 10, 2002·Melanoma Research·P B ChapmanW-J Hwu
Sep 16, 2003·Cancer Treatment Reviews·Anita GothelfJulie Gehl
Feb 1, 1961·The Journal of Immunology : Official Journal of the American Association of Immunologists·H J WINN
Nov 26, 2003·Immunology and Cell Biology·Shala DezfouliStephen J Ralph
Dec 4, 2003·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·M G O'BrienG C O'Sullivan
Mar 6, 2004·Seminars in Cancer Biology·Mads Hald AndersenPer thor Straten
May 14, 2005·Cancer Immunology, Immunotherapy : CII·Adam T C CheukBarbara-ann Guinn
May 19, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Loree HellerRichard Heller
Jul 29, 2006·Cancer Gene Therapy·C G CollinsG C O'Sullivan
Citations
Feb 27, 2010·Cancer Gene Therapy·M C WhelanG C O'Sullivan
Feb 13, 2009·Gene Therapy·M CemazarJ Teissie
Dec 22, 2010·Genetic Vaccines and Therapy·Sara A CollinsMark Tangney
Aug 7, 2010·Journal of Visualized Experiments : JoVE·Simon RajendranMark Tangney
Jan 15, 2011·Cancer Treatment Reviews·M G BourkeG C O'Sullivan
Mar 30, 2011·Experimental Biology and Medicine·Simon RajendranMark Tangney
Jul 27, 2021·Frontiers in Oncology·Karl-Göran Tranberg