Immune genes undergo more adaptive evolution than non-immune system genes in Daphnia pulex.

BMC Evolutionary Biology
Seanna J McTaggartTom J Little

Abstract

Understanding which parts of the genome have been most influenced by adaptive evolution remains an unsolved puzzle. Some evidence suggests that selection has the greatest impact on regions of the genome that interact with other evolving genomes, including loci that are involved in host-parasite co-evolutionary processes. In this study, we used a population genetic approach to test this hypothesis by comparing DNA sequences of 30 putative immune system genes in the crustacean Daphnia pulex with 24 non-immune system genes. In support of the hypothesis, results from a multilocus extension of the McDonald-Kreitman (MK) test indicate that immune system genes as a class have experienced more adaptive evolution than non-immune system genes. However, not all immune system genes show evidence of adaptive evolution. Additionally, we apply single locus MK tests and calculate population genetic parameters at all loci in order to characterize the mode of selection (directional versus balancing) in the genes that show the greatest deviation from neutral evolution. Our data are consistent with the hypothesis that immune system genes undergo more adaptive evolution than non-immune system genes, possibly as a result of host-parasite arms races....Continue Reading

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Citations

Feb 6, 2013·Proceedings of the National Academy of Sciences of the United States of America·Tal ShayUNKNOWN ImmGen Consortium
Dec 3, 2014·Developmental and Comparative Immunology·Katherine M Buckley, Jonathan P Rast
Feb 18, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Silvio ErlerH Michael G Lattorff
Jul 27, 2014·Current Opinion in Virology·Darren J Obbard, Gytis Dudas
Mar 28, 2016·Genome Biology and Evolution·Jana AsselmanKarel A C De Schamphelaere
Jan 13, 2018·Proceedings. Biological Sciences·Emily L BehrmanPaul S Schmidt
Mar 5, 2019·Genome Biology and Evolution·Anna MarcionettiNicolas Salamin
Jan 2, 2015·G3 : Genes - Genomes - Genetics·Susan M RottschaeferBrian P Lazzaro
Sep 19, 2019·Proceedings. Biological Sciences·Jenna Kay Lea, Robert L Unckless
Mar 7, 2020·Immunology and Cell Biology·Miles B HortonPhilip D Hodgkin
Nov 7, 2016·Genetics·Angela M EarlyAndrew G Clark
Sep 19, 2017·Veterinary World·Ankita GuraoRavinder Singh
Sep 11, 2019·Genome Biology and Evolution·Joanne R ChapmanRobert L Unckless

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Methods Mentioned

BETA
PCR

Software Mentioned

Test
PHASE
DnaSP
SeqMan
DNAstar
MKtest
MK
Primer

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