Immune Infiltration in Invasive Lobular Breast Cancer

Journal of the National Cancer Institute
Christine DesmedtChristos Sotiriou

Abstract

Invasive lobular breast cancer (ILC) is the second most common histological subtype of breast cancer after invasive ductal cancer (IDC). Here, we aimed at evaluating the prevalence, levels, and composition of tumor-infiltrating lymphocytes (TILs) and their association with clinico-pathological and outcome variables in ILC, and to compare them with IDC. We considered two patient series with TIL data: a multicentric retrospective series (n = 614) and the BIG 02-98 study (n = 149 ILC and 807 IDC). We compared immune subsets identified by immuno-histochemistry in the ILC (n = 159) and IDC (n = 468) patients from the Nottingham series, as well as the CIBERSORT immune profiling of the ILC (n = 98) and IDC (n = 388) METABRIC and The Cancer Genome Atlas patients. All ILC/IDC comparisons were done in estrogen receptor (ER)-positive/human epidermal growth factor receptor 2 (HER2)-negative tumors. All statistical tests were two-sided. TIL levels were statistically significantly lower in ILC compared with IDC (fold-change = 0.79, 95% confidence interval = 0.70 to 0.88, P < .001). In ILC, high TIL levels were associated with young age, lymph node involvement, and high proliferative tumors. In the univariate analysis, high TIL levels were as...Continue Reading

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Citations

Dec 14, 2019·Current Opinion in Obstetrics & Gynecology·Marcus Schmidt
Mar 27, 2020·Medical Sciences : Open Access Journal·Ugo TestaElvira Pelosi
Sep 18, 2020·Cellular and Molecular Life Sciences : CMLS·Fabrizio Marcucci, Cristiano Rumio
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Sep 19, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·François RichardChristine Desmedt
Feb 12, 2021·Breast Cancer Research : BCR·Mattias AineJohan Staaf
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Sep 7, 2021·Breast Cancer Research and Treatment·Peter SavasSherene Loi

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Software Mentioned

METABRIC
CIBERSORT

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