Immune-inflammatory pathways and clinical changes in fibromyalgia patients treated with Mindfulness-Based Stress Reduction (MBSR): A randomized, controlled clinical trial

Brain, Behavior, and Immunity
Laura Andrés-RodríguezJuan V Luciano

Abstract

Fibromyalgia (FM) is a highly prevalent and disabling syndrome characterized by chronic widespread musculoskeletal pain and a broad range of cognitive and affective symptoms. Up to now, the pathogenesis of FM is unknown although a peripheral and central sensitization involving an imbalance on immune biomarkers appears to have a relevant role in its aetiology. The aim of this study was to extend previous clinical findings of Mindfulness-Based Stress Reduction (MBSR) to both its impact on clinical symptomatology and immune biomarkers (IL-6, CXCL8, IL-10 and hs-CRP), and also to explore the role of biomarkers as predictors of efficacy. A total of 70 female patients with FM were randomly assigned to two treatment modalities, namely Treatment as Usual (TAU) plus MBSR (n = 35) or TAU alone (n = 35). This study is embedded within a larger RCT (n = 225) that includes three study arms (TAU; TAU plus MBSR; and TAU plus the psychoeducative intervention FibroQoL), and a 12-month follow-up (clinical trial registration: NCT02561416). Blood cytokine assays and clinical assessment were conducted at baseline and post-treatment. Treatment effects were analysed using linear mixed models with intention to treat and per protocol analyses. In order ...Continue Reading

Citations

Feb 7, 2020·Journal of Advanced Nursing·Nora Suleiman-MartosLuis Albendín-García
Jul 23, 2020·General Psychiatry·Hui ShenDonghong Cui
Apr 14, 2020·Reumatología clinica·Diego Felipe García Rodríguez, Carlos Abud Mendoza
Mar 25, 2021·The Journal of Pain : Official Journal of the American Pain Society·Carolyn BerrymanG Lorimer Moseley
Jan 15, 2022·Medicine and Science in Sports and Exercise·Karin WåhlénBijar Ghafouri

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