Immune interaction between components of acellular pertussis-diphtheria-tetanus (DTaP) vaccine and Haemophilus influenzae b (Hib) conjugate vaccine in a rat model

Vaccine
Fatme MawasMichael J Corbel

Abstract

We have previously shown that, consistent with clinical trial results, the immune response to a Haemophilus influenzae b (Hib) conjugate vaccine in a rat model was compromised and modulated when given combined with a DTaP3 vaccine, as compared to both vaccines given separately. The present study extended our investigation to evaluate the immunogenicity of all DTaP3 components in combined versus separate administration of Hib with DTaP3 and investigated immune interactions between Hib and individual components of DTaP3. Rats were immunised with Hib and DTaP3 or with Hib and individual DTaP3 components. Cellular and humoral immune responses to Hib and DTaP3 components were evaluated. Our results indicate that the immunogenicity of DTaP3 components was similar or greater in combined versus separate administration of Hib and DTaP3. Moreover, combined administration of Hib and TT reduced immunogenicity of both Hib and TT. Hib immunogenicity was also significantly reduced when given combined with FHA and following adsorption to Al(OH)3.

Citations

May 17, 2011·Journal of Global Infectious Diseases·David Ag SkibinskiDerek T O'Hagan
Oct 7, 2009·Expert Review of Vaccines·Michael J Corbel, Maria de Los Angeles Cortes Castillo
Jul 22, 2015·Biologicals : Journal of the International Association of Biological Standardization·Robert B D OttoBarbara Bolgiano
Apr 22, 2015·Human Vaccines & Immunotherapeutics·Malabi M Venkatesan, Lillian L Van de Verg
Jun 2, 2015·Environmental Health Perspectives·Julia R Barrett

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