PMID: 6170714Nov 1, 1981Paper

Immune interferon produced to high levels by antigenic stimulation of human lymphocytes with influenza virus

The Journal of Experimental Medicine
F A Ennis, A Meager

Abstract

Influenza virus stimulation of human lymphocytes induced high levels of immune interferon in lymphocyte cultures. The lymphocytes of normal adults produced approximately 1,000 U/10(6) cells, which was in large part gamma interferon. The lymphocytes of individuals recently vaccinated yielded very high levels (10-50,000 U/10(6) cells) of interferon. The interferon was pH 2 labile, and was not neutralized by antisera to alpha or beta interferon. It did not bind to a monoclonal antibody to alpha interferon, and after partial purification it had characteristics identical to human gamma interferon induced by phytohemagglutinin. The highest yields were produced by treatment of stimulator cells with live virus. Stimulation by whole inactivated virus resulted in lower levels of interferon, and purified hemagglutinin did not induce interferon. The antigen responsible for stimulating the lymphocyte response and interferon induction is a cross-reactive determinant present on all human and non-human influenza viruses tested.

References

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Citations

Mar 18, 1985·Journal of Immunological Methods·I J CraneA Meager
Mar 28, 1996·Journal of Immunological Methods·J E McElhaneyR C Bleackley
Feb 1, 1989·Veterinary Immunology and Immunopathology·L D PearsonJ C Demartini
Sep 1, 1988·Immunology Letters·F Suzuki, R B Pollard
Jan 1, 1986·International Journal of Immunopharmacology·S E ChristmasM Moore
Sep 5, 2013·Pediatric Research·Eutichia PetrakouMarietta Xanthou
Aug 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·T W ChangJ Le
Apr 1, 1982·The Journal of Experimental Medicine·J R KleinM J Bevan
Mar 1, 1983·The Journal of Experimental Medicine·F R BalkwillP C Beverley
Oct 1, 1983·The Journal of Experimental Medicine·B PerussiaG Trinchieri
Oct 1, 1987·The Journal of Experimental Medicine·I Kurane, F A Ennis
Jan 1, 1982·Journal of Interferon Research·A MeagerJ Vilcek
Jan 1, 1990·Microbiology and Immunology·H HasegawaY Kobayashi
Feb 1, 1987·The Journal of Clinical Investigation·D Y LeungR S Geha
Nov 1, 1984·Scandinavian Journal of Immunology·U AnderssonS Modrow
Mar 10, 2001·Microbiology and Molecular Biology Reviews : MMBR·T H Mogensen, S R Paludan
Jan 1, 1992·Journal of the American Geriatrics Society·D C Powers
May 1, 1986·Journal of Clinical Microbiology·A D D'AndreaR A Polin

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