PMID: 2491638Jan 1, 1989Paper

Immune mechanisms in the pathogenesis of demyelinating diseases

Autoimmunity
N ScoldingA Compston

Abstract

The loss of myelin which characterises many human and experimental demyelinating diseases, among them multiple sclerosis, is thought to be immune mediated, but the precise mechanisms responsible remain unknown despite intense research. Normally, myelin in the central nervous system (CNS) is protected from systemic immune responses by the blood brain barrier, which separates nervous tissue from the peripheral circulation. Here we review evidence suggesting that an understanding of the demyelinating disorders may be helped by considering their immune pathogenesis in two stages. The first is damage to the blood brain barrier; this appears to be cell mediated, and allows infiltration into the CNS of other immune effectors. These include complement and also macrophages, which together may mediate the second stage, injury to the myelin/oligodendrocyte complex.

References

Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·W CammerS Gordon
Sep 1, 1978·Neurology·J W Prineas, F Connell
Jun 1, 1975·Journal of the Neurological Sciences·C W Adams
Feb 1, 1986·Journal of Neuroimmunology·S W Brostoff, D W Mason
Aug 1, 1989·Brain : a Journal of Neurology·C LiningtonD A Compston
Jan 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·J KesselringW I McDonald
Apr 1, 1988·Annals of Neurology·K W Selmaj, C S Raine
Aug 1, 1988·Annals of Neurology·M S Freedman, J P Antel
Aug 1, 1987·Journal of the Neurological Sciences·G M HayesM L Cuzner
Jan 1, 1988·Archives of Disease in Childhood·B Connolly, R J Fitzgerald
Aug 1, 1988·Brain : a Journal of Neurology·D H MillerW I McDonald
Feb 1, 1986·Gastrointestinal Endoscopy·A SalmiF Buffoli
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·W F Hickey, H Kimura
Nov 1, 1986·Neurology·D A CompstonA K Campbell
Feb 1, 1985·Journal of Neuroimmunology·G H WongJ W Schrader
Aug 1, 1985·Cancer Genetics and Cytogenetics·M R MacKenzie, J P Lewis
Jul 1, 1985·Journal of the Neurological Sciences·C W AdamsH Vipond
Oct 1, 1974·Journal of Neuropathology and Experimental Neurology·W H Oldendorf, H F Towner
May 21, 1971·Brain Research·C E Lumsden
Jul 1, 1970·Journal of Neuropathology and Experimental Neurology·A HiranoH M Zimmerman
Feb 1, 1971·Proceedings of the Society for Experimental Biology and Medicine·H PabstR A Good
Jan 1, 1965·Acta neurochirurgica·J W BeksW G Walter

❮ Previous
Next ❯

Citations

May 1, 1991·Trends in Neurosciences·A CompstonM Noble
Jun 1, 1994·Progress in Neurobiology·N J ScoldingD A Compston
Mar 4, 1994·Journal of Chromatography. B, Biomedical Applications·J M van NoortA C van Sechel
Jul 1, 1997·Mayo Clinic Proceedings·C F Lucchinetti, M Rodriguez
Apr 25, 2000·Multiple Sclerosis : Clinical and Laboratory Research·J IriarteP Castro
Mar 1, 2000·Multiple Sclerosis : Clinical and Laboratory Research·S AdlerJ G Verbalis
Nov 25, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Richard James MeadBryan Paul Morgan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.