PMID: 540May 15, 1975

Immune mechanisms in uremia

Klinische Wochenschrift
H Dobbelstein

Abstract

There is both clinical and experimental evidence that cellular and humoral immunity are suppressed in patients with renal insufficiency: observations in organ transplantation and in vitro stimulation of lymphocytes from uraemic patients, investigations of acute and late hypersensitivity reactions, the immune response after active immunization as well as changes of immunoglobulins and lymphatic organs in uraemia are discussed in the paper. The underlying mechanisms are complex and not yet fully understood. Lymphopenia, atrophy of the thymus gland, toxic serum factors, induction of enhancing mechanisms by certain serum fractions and metabolic defects of lymphocytes--all were shown to be involved or at least considered to be. At present, however, it is impossible to define their rank of importance and the exact place they may occupy in the genesis of this type of "natural immunosuppression".

References

May 15, 1973·Klinische Wochenschrift·A Fateh-MoghadamK Schneemilch
Jan 3, 1969·Deutsche medizinische Wochenschrift·P G ScheurlenG Sieberth
Sep 11, 1969·The New England Journal of Medicine·W T LondonB S Blumberg
Apr 1, 1969·Klinische Wochenschrift·J Oehme, D Meyer-Beeck
Oct 15, 1974·Klinische Wochenschrift·E HeldH J Gurland
Jan 1, 1974·Transplantation·G NirmulR N Taub
Aug 1, 1972·The Journal of Urology·J E HarrisT Stewart
Aug 1, 1971·Journal of Medical Microbiology·O P van Bijsterveld
Feb 1, 1971·The American Journal of Clinical Nutrition·A E AXELROD
Jun 1, 1968·The Journal of Nutrition·S N GershoffA I Steinberg
Feb 1, 1955·The Journal of Clinical Investigation·D M HUMEG W THORN
Jan 1, 1955·Vitamins and Hormones·A E AXELROD, J PRUZANSKY
Mar 22, 1957·Annals of the New York Academy of Sciences·G J DAMMINJ E MURRAY
Aug 14, 1958·The New England Journal of Medicine·I L STOLOFFW P HAVENS
Jan 1, 1964·Vitamins and Hormones·A E AXELROD, A C TRAKATELLIS
Jan 1, 1960·International Archives of Allergy and Applied Immunology·B J HARGISS MALKIEL
May 1, 1946·Proceedings of the Society for Experimental Biology and Medicine·H C STOERK, H N EISEN

Citations

Jan 1, 1985·Upsala Journal of Medical Sciences·W RoszkowskiM Kopeć
Jan 1, 1980·Scandinavian Journal of Gastroenterology·W ArnoldK H Meyer zum Büschenfelde
Jan 1, 1977·International Urology and Nephrology·L Váry, J Juhász

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