Immune mechanisms of HIV control.

Current Opinion in Immunology
Lisa A Chakrabarti, Viviana Simon

Abstract

HIV-1 can be contained by the immune system, as demonstrated by the existence of rare individuals who spontaneously control HIV-1 replication in the absence of antiretroviral therapy. Emerging evidence points to the importance of a very active cellular immune response in mediating HIV-1 control. The rapid induction of interferon-dependent HIV restriction factors, the presence of protective MHC class I alleles, and the development of a high avidity T-cell response may all cooperate in limiting HIV replication at an early stage. This review will focus on recent advances in understanding the immune mechanisms of HIV control, and on the lessons that may be drawn for the development of candidate HIV vaccines.

Citations

Oct 20, 2010·Immunology and Cell Biology·Danushka K WijesundaraCharani Ranasinghe
Jul 9, 2011·Nature Immunology·Brian S Sheridan, Leo Lefrançois
Dec 18, 2013·Nature Reviews. Immunology·Donna L FarberNicholas P Restifo
Jul 17, 2012·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Claudia J DembekAntonio Cosma
Mar 25, 2015·Journal of Neurovirology·Jerome H Chin
Apr 26, 2016·The Journal of Clinical Investigation·Daniela BenatiLisa A Chakrabarti
Jul 20, 2016·Journal of Neurovirology·Tatiana KoudriavtsevaFulvia Pimpinelli
Oct 11, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Madhura MukhopadhyayLisa A Chakrabarti
Apr 12, 2019·Current Opinion in HIV and AIDS·Arnaud MorisLisa Chakrabarti
Jul 8, 2011·Current Opinion in HIV and AIDS·Magdalena E SobieszczykM Juliana McElrath
Apr 19, 2015·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Theodros S TsegayeEllen N Kersh

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