Immune mechanisms of resistance to gastrointestinal nematode infections in sheep

Parasite Immunology
W R HeinE N Meeusen

Abstract

Infections with gastrointestinal nematode parasites are a major problem for the sheep industry in Australia and New Zealand and have been the subject of intensive research to define mechanisms of resistance. The ability to take continuous biopsy samples of infected organs and cannulate both afferent and efferent lymphatics of draining lymph nodes has been particularly useful in illuminating the kinetics of immune responses at the site of infection. Distinct localized immune responses were shown to occur within and between sheep breeds at different sensitization regimes, as well as at different developmental stages of the parasite within the host. Using localized antibodies derived from mucus and lymph nodes, two major antigens have been identified on the infective L3 stage, which may be responsible for inducing protection and have potential as vaccine targets. Recent advances in sheep genomics also offer the potential of gaining further insight into the underlying genetics of resistance to nematode infections.

Citations

Feb 23, 2013·Veterinary Research Communications·Virginia M VenturinaJohn Hopkins
Jul 31, 2012·Veterinary Immunology and Immunopathology·A PernthanerI A Sutherland
Sep 14, 2010·Trends in Parasitology·David PiedrafitaEls Meeusen
Nov 22, 2011·The Veterinary Journal·Andrew R Williams, Dieter G Palmer
Feb 2, 2013·Veterinary Immunology and Immunopathology·Melanie R NeelandMichael J de Veer
Oct 25, 2016·International Journal for Parasitology·David L EmeryLeo F Le Jambre
Oct 9, 2015·Revista brasileira de parasitologia veterinária = Brazilian journal of veterinary parasitology : Órgão Oficial do Colégio Brasileiro de Parasitologia Veterinária·Bárbara Maria Paraná da Silva SouzaMaria Angela Ornelas de Almeida

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