Immune-mediated adverse drug reactions

Chemical Research in Toxicology
Jack Uetrecht

Abstract

Many adverse drug reactions are mediated by the immune system. This can be because the therapeutic effect of the drug targets the immune system. For example, immunosuppressive drugs increase the risk of infections. It is paradoxical that some immunosuppressive drugs can lead to autoimmune reactions. Another mechanism by which drugs can cause an adverse reaction involves an idiosyncratic response to the drug such as an immune-mediated skin rash. These idiosyncratic drug reactions (IDRs) are difficult to study because of the paucity of valid animal models and their unpredictable nature. Therefore, much of our mechanistic knowledge of IDRs is based on inferences from the clinical characteristics of IDRs rather than on controlled mechanistic studies. In general, IDRs are associated with a delay between starting the drug and the onset of the adverse reaction, and the typical delay is different for different types of IDRs. In contrast, on rechallenge, there is usually a rapid onset of the adverse reaction, which is characteristic of an amnestic immune response. The absence of such a rapid response is usually considered evidence that an IDR is not immune-mediated; yet, there are immune-mediated IDRs that do not have an amnestic respon...Continue Reading

References

May 23, 1992·Lancet·A Z SaffermanA Howard
Mar 1, 1988·Blood Reviews·W G Murphy, J G Kelton
Jan 1, 1986·Scandinavian Journal of Haematology·M R KramerC Hershko
Mar 1, 1983·European Journal of Pediatrics·B A Vanheule, F Carswell
Jan 21, 1984·British Medical Journal·A P MooreP Hillenbrand
Nov 1, 1982·Annals of Internal Medicine·A ChalmersA C Patterson
Mar 1, 1981·Clinical Pharmacokinetics·J P Uetrecht, R L Woosley
Jul 15, 1993·The New England Journal of Medicine·J M AlvirJ A Schaaf
Oct 1, 1996·Chemical Research in Toxicology·M BourdiL R Pohl
Feb 4, 1998·Current Opinion in Rheumatology·P A Merkel
Dec 16, 1998·Cellular and Molecular Life Sciences : CMLS·M KarpusasP Hochman
Mar 4, 1999·Journal of the Neurological Sciences·L DurelliG Aimo
Jul 16, 1999·Seminars in Arthritis and Rheumatism·O ElkayamD Caspi
Jun 22, 2000·Molecular Pharmacology·D P WilliamsB K Park
Aug 2, 2000·Journal of Gastroenterology and Hepatology·A Chutaputti
Apr 26, 2001·The New England Journal of Medicine·T E Warkentin, J G Kelton
Oct 26, 2002·Chemico-biological Interactions·Izet M KapetanovicHarvey J Kupferberg
Nov 15, 2002·The New England Journal of Medicine·Jan de GansUNKNOWN European Dexamethasone in Adulthood Bacterial Meningitis Study Investigators
Dec 17, 2002·Chemical Research in Toxicology·Cynthia JuLance R Pohl
Dec 18, 2002·Annals of Internal Medicine·George OstapowiczUNKNOWN U.S. Acute Liver Failure Study Group
Jan 25, 2003·The Journal of Investigative Dermatology·Carle F PaulLouis Dubertret
Mar 5, 2003·The American Journal of Cardiology·Carl J Vaughan
Apr 17, 2003·The Journal of Clinical Investigation·Imke TiedeMarkus F Neurath
May 20, 2003·British Journal of Haematology·Theodore E Warkentin
Jul 17, 2003·Current Opinion in Allergy and Clinical Immunology·Béatrice Séguin, Jack Uetrecht
Sep 10, 2003·Current Opinion in Rheumatology·Insoo Kang, Sung Hwan Park
Oct 22, 2003·Annals of Internal Medicine·Werner J Pichler
Oct 31, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Bruce Richardson
Jul 3, 2004·BMJ : British Medical Journal·Munir PirmohamedAlasdair M Breckenridge
Sep 7, 2004·Current Opinion in Allergy and Clinical Immunology·Marianne Lerch, Werner J Pichler
Nov 13, 2004·Journal of Clinical Psychopharmacology·Igor MosyaginIngolf Cascorbi

❮ Previous
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Citations

Oct 20, 2009·European Journal of Clinical Pharmacology·Carlo PiccinniNicola Montanaro
Apr 3, 2012·Chemical Research in Toxicology·Yakov M KoenRobert P Hanzlik
Apr 24, 2012·Journal of Veterinary Internal Medicine·K L VoieS N Lavergne
Mar 12, 2013·Pharmacological Reviews·Jack Uetrecht, Dean J Naisbitt
Oct 28, 2010·Drug Metabolism and Pharmacokinetics·F Peter Guengerich
Nov 19, 2010·Drug Metabolism and Pharmacokinetics·Xiaochu ZhangJack Uetrecht
Jul 20, 2010·Future Medicinal Chemistry·Douglas S JohnsonBenjamin F Cravatt
Mar 8, 2013·Chemical Research in Toxicology·Yakov M KoenRobert P Hanzlik
Oct 3, 2013·Journal of Immunotoxicology·Michael I Luster
Nov 13, 2013·Expert Review of Clinical Immunology·Adriana ArizaMaría José Torres
May 23, 2012·Expert Opinion on Drug Discovery·Amit S Kalgutkar, Deepak K Dalvie
Aug 23, 2012·Journal of Pharmaceutical Sciences·Malcolm RowlandVinod P Shah
Jan 23, 2016·Veterinary Dermatology·Emilie RoyauxSophie Vandenabeele
Feb 11, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·María I MontañezEzequiel Perez-Inestrosa
Oct 17, 2014·Clinical and Molecular Hepatology·Reza HeidariNarges Abdoli
Mar 5, 2014·Veterinary Anaesthesia and Analgesia·Stacy L AndersonBaljit Singh
Sep 14, 2012·Journal of Immunotoxicology·Winnie Ng, Jack Uetrecht
Feb 15, 2014·Journal of Toxicologic Pathology·Motoko FukuiShigeru Hisada
Jun 21, 2013·American Journal of Therapeutics·Somnath MookherjeeKelly L Wentworth
Jan 1, 2013·Toxicology Research·Dominic P WilliamsStuart Creton
Jun 1, 2012·Chemical Research in Toxicology·Richard A ThompsonJ Gerry Kenna
Oct 22, 2016·Digestive Diseases and Sciences·Anastasiya Latushko, Leyla J Ghazi
Feb 7, 2017·Veterinary Dermatology·Jacqueline V J CavalcantiPaulo Vilar Saavedra
Jul 21, 2017·International Journal of Molecular Sciences·Jasleen K SodhiS Cyrus Khojasteh
Apr 2, 2011·Nature Reviews. Drug Discovery·Juswinder SinghAdrian Whitty
Apr 23, 2011·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Toru UsuiSetsuko Komuro
Jul 8, 2010·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Ryoko SawamuraOsamu Okazaki
Jan 11, 2020·Journal of Leukocyte Biology·Andrea MencarelliQingfeng Chen
Jun 11, 2011·Current Opinion in Allergy and Clinical Immunology·Adriana ArizaDolores Pérez-Sala
Jun 6, 2020·Expert Opinion on Drug Metabolism & Toxicology·Jingheng WangTaosheng Chen
Nov 9, 2010·Molecular Diagnosis & Therapy·Abdelbaset A ElzagallaaiGideon Koren
Apr 27, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Noemi MolinaEzequiel Perez-Inestrosa

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