Immune-mediated hemolytic anemia and severe thrombocytopenia in dogs: 12 cases (2001-2008)

Journal of Veterinary Emergency and Critical Care
Elizabeth S OrcuttDomenico Bianco

Abstract

To identify and characterize the syndrome of immune-mediated hemolytic anemia (IMHA) with concurrent severe thrombocytopenia (<or=15.0 x 10(9) platelets/L; [15.0 x 10(3) platelets/microL]), and to evaluate prognostic factors, clinicopathologic findings, complications, treatment, outcome, and survival of dogs with this hematologic disorder. Retrospective, observational study. Veterinary teaching hospital. Twelve client-owned dogs with IMHA and severe thrombocytopenia (<or=15.0 x 10(9) platelets/L; [15.0 x 10(3) platelets/microL]), without evidence of overt disseminated intravascular coagulation. The following data were recorded and analyzed from the electronic medical record: signalment, history, concurrent diseases, clinical signs at presentation, clinicopathologic data, diagnostic testing, radiographic findings, treatment modalities, length of hospitalization, complications, and clinical outcome. All dogs were treated with immunosuppressive doses of corticosteroids. Twelve dogs were identified with the diagnosis of IMHA and severe thrombocytopenia; of these, 9 (75%) survived, 3 (25%) were euthanized, and none died. Dogs that survived were significantly younger than nonsurvivors (P=0.03). There were no specific clinical signs o...Continue Reading

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Citations

Feb 10, 2012·Journal of Veterinary Emergency and Critical Care·Reid K NakamuraDomenico Bianco
Jan 3, 2013·Journal of Veterinary Internal Medicine·J W Swann, B J Skelly
Feb 27, 2019·Journal of Veterinary Internal Medicine·Oliver A GardenBalazs Szladovits
Oct 30, 2010·The Journal of Small Animal Practice·S M WarmanS Tasker
Mar 9, 2019·Journal of Veterinary Internal Medicine·James W SwannNathaniel T Whitley
Nov 11, 2020·Equine Veterinary Journal·Charlotte A Easton-JonesK Gary Magdesian
Aug 11, 2021·Journal of Veterinary Internal Medicine·Eoin KilkennyKieran Borgeat

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