PMID: 8458712Jan 1, 1993Paper

Immune-mediated injury in bacterial meningitis

International Review of Experimental Pathology
K FreiA Fontana

Abstract

Cytokines are involved in the host response to bacterial infections. In bacterial meningitis, intrathecal synthesis of TNF-alpha and IL-1 is likely to contribute to CNS injury by recruitment and activation of inflammatory cells with subsequent release of toxic factors, such as reactive oxygen intermediates and excitatory amino acids (glutamate), leading to neuronal cell death with neurologic sequelae. In rats with experimental meningitis, pretreatment with TGF-beta inhibits cerebrovascular changes and brain edema formation in the early, TNF-alpha-independent phase. Provided its local production in bacterial infection, TGF-beta may comprise a host factor interfering with immune pathologic events altering the integrity of the endothelial barrier.

Citations

Mar 1, 1997·Journal of Neurosurgery·S HolminT Mathiesen
Sep 1, 2007·Neurosurgery·Robert Trombly, James D Guest
Mar 3, 1998·Neurosurgery·S HolminT Mathiesen
Dec 1, 2002·Acta Neuropsychiatrica·Carlos R Plata-Salaman

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