Immune-mediated Liver Injury in Hepatitis B Virus Infection

Immune Network
In Soo Oh, Su-Hyung Park

Abstract

Hepatitis B virus (HBV) is responsible for approximately 350 million chronic infections worldwide and is a leading cause of broad-spectrum liver diseases such as hepatitis, cirrhosis and liver cancer. Although it has been well established that adaptive immunity plays a critical role in viral clearance, the pathogenetic mechanisms that cause liver damage during acute and chronic HBV infection remain largely known. This review describes our current knowledge of the immune-mediated pathogenesis of HBV infection and the role of immune cells in the liver injury during hepatitis B.

References

Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A BertolettiF V Chisari
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·G AcsH Popper
Feb 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M A SellsG Acs
Jan 1, 1983·Springer Seminars in Immunopathology·N R Cooper, G R Nemerow
Nov 1, 1995·The Journal of Experimental Medicine·P R GalleL Runkel
Jan 1, 1995·Annual Review of Immunology·F V Chisari, C Ferrari
Oct 1, 1995·Journal of Virology·L G GuidottiF V Chisari
Dec 19, 1995·Proceedings of the National Academy of Sciences of the United States of America·L V TsuiF V Chisari
Apr 1, 1997·Nature Medicine·T KondoS Nagata
Aug 5, 1997·Proceedings of the National Academy of Sciences of the United States of America·F Su, R J Schneider
Jul 1, 1997·Cell Biology and Toxicology·K O LindrosS S Thorgeirsson
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·L W ElmoreC C Harris
Mar 30, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S LocaputoJ A Bezerra
Jun 8, 1999·Annual Review of Immunology·C A BironT P Salazar-Mather
Mar 8, 2000·Microbiology and Molecular Biology Reviews : MMBR·C Seeger, W S Mason
Feb 7, 2001·Journal of Virology·C Servet-DelpratC Rabourdin-Combe
Apr 25, 2000·Virology·D R BurtonP W Parren
Nov 28, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D Shouval, D Samuel
Oct 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·A KrtolicaJ Campisi
Nov 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Andrew I SuFrancis V Chisari
Apr 5, 2003·The Journal of Biological Chemistry·Yumiko Shirakata, Katsuro Koike
May 24, 2003·Journal of Hepatology·Henning Schulze-BergkamenUlrike Protzer
May 30, 2003·The EMBO Journal·Hiroyuki MarusawaJohn C Reed
Jan 8, 2004·Journal of Hepatology·Carlo FerrariSimona Urbani
Mar 12, 2004·The New England Journal of Medicine·Don Ganem, Alfred M Prince
Apr 22, 2004·Proceedings of the National Academy of Sciences of the United States of America·Stefan WielandFrancis V Chisari
Feb 24, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Simona UrbaniCarlo Ferrari
Mar 2, 2005·Nature Reviews. Immunology·Barbara Rehermann, Michelina Nascimbeni

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Citations

May 26, 2017·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Lina CaoQiushui He
Nov 24, 2019·Naunyn-Schmiedeberg's Archives of Pharmacology·Rui-Jun ZhouMei-Lin Xie
Dec 4, 2019·Oncology Letters·Dan GuoBing Chen
May 31, 2016·World Journal of Gastroenterology : WJG·Mohammad IrshadMohammad Ahmad Ansari
Oct 1, 2018·Journal of Translational Medicine·Liang DuanWeixian Chen
Dec 7, 2018·Journal of Veterinary Internal Medicine·Joy E TomlinsonThomas J Divers
Nov 7, 2019·Oxidative Medicine and Cellular Longevity·Weitao JiXinrui Lv
Nov 5, 2020·PLoS Genetics·Matthew R DewhurstPhilipp Kaldis
Dec 12, 2020·Journal of Viral Hepatitis·Curtis CooperCarla S Coffin
Sep 5, 2017·Biochemical and Biophysical Research Communications·Rui-Jun ZhouMei-Lin Xie
Jun 3, 2021·International Journal of Molecular Sciences·Arshi KhanamShyam Kottilil
Oct 6, 2021·Communications Biology·Jeffrey S DamrauerKatherine A Hoadley

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Methods Mentioned

BETA
transgenic

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