Immune mediated necrotizing myopathy: A rare complication of statin therapy

Clinics and Practice
Shady Piedra AbushararHyma V Polimera

Abstract

Immune mediated necrotizing myopathy (IMNM) is part of the inflammatory myopathies group of diseases and presents with muscle weakness, myalgias and elevated serum creatine phosphokinase (CPK). Statin-induced IMNM is a rare complication. We present a patient with IMNM secondary to simvastatin use. The patient presented with proximal myopathy, dysphagia, and elevated creatinine kinase levels, and was subsequently found to have anti-3- hydroxy-3-methylglutaryl-CoA reductase (HMGCR) autoantibodies with a necrotizing process on muscle biopsy. This patient's case was further complicated by sequelae of multiple disease processes, ultimately leading to deterioration of his health.

References

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Dec 10, 2017·Neuromuscular Disorders : NMD·Yves AllenbachUNKNOWN Immune-Mediated Necrotizing Myopathies Working Group
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Methods Mentioned

BETA
biopsy
biopsies

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