Immune modulation in suckling rat pups by a growth factor extract derived from milk whey

The Journal of Dairy Research
I A PenttilaH Zola

Abstract

Oral tolerance to foreign enteral antigens is not fully developed in early neonatal life. Epidemiological evidence supports a role for maternal milk in the development of immune responses, including oral tolerance. Formula fed infants have an increased susceptibility to food allergy and the later development of autoimmune disease. This may relate to the lack in infant formula of growth factors found in maternal milk. Bovine milk contains proteins, growth factors and cytokines. Various studies have outlined the immune modulating potential of bovine milk-derived products. Fractionated whey extracts have therapeutic potential in disease states where there is an excessive inflammatory reaction, and disease preventive potential for infants who are not breast-fed. We have shown that daily oral administration of a growth factor-enriched fraction from milk whey to naturally suckling rat pups between days 4-9 postnatal can down-regulate immune activation to a specific orally administered food antigen, ovalbumin, assessed by lymphocyte proliferation. In addition, non-specific down-regulation in the intestine was observed as assessed by the expression of MHC I. Treatment of rat pups with whey extract at the time of oral sensitisation to o...Continue Reading

Citations

Dec 11, 2007·Canadian Journal of Physiology and Pharmacology·Réjean DrouinChristina Juneau
Apr 16, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·W H Oddy, R J McMahon
Jul 15, 2009·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Wendy H Oddy, Francisco Rosales
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