Immune monitoring after pediatric liver transplantation - the prospective ChilSFree cohort study

BMC Gastroenterology
Imeke GoldschmidtUlrich Baumann

Abstract

Although trough levels of immunosuppressive drugs are largely used to monitor immunosuppressive therapy after solid organ transplantation, there is still no established tool that allows for a validated assessment of functional degree of immunosuppression or the identification of clinically relevant over- or under-immunosuppression, depending on graft homeostasis. Reliable non-invasive markers to predict biopsy proven acute rejection (BPAR) do not exist. Literature data suggest that longitudinal measurements of immune markers might be predictive of BPAR, but data in children are scarce. We therefore propose an observational prospective cohort study focusing on immune monitoring in children after liver transplantation. We aim to describe immune function in a cohort of children before and during the first year after liver transplantation and plan to investigate how the immune function profile is associated with clinical and laboratory findings. In an international multicenter prospective approach, children with end-stage liver disease who undergo liver transplantation are enrolled to the study and receive extensive immune monitoring before and at 1, 2, 3, 4 weeks and 3, 6, 12 months after transplantation, and whenever a clinically...Continue Reading

References

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Mar 23, 2017·Biometrical Journal. Biometrische Zeitschrift·Elisabeth WaldmannAndreas Mayr

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Citations

Jun 26, 2020·Frontiers in Immunology·Helong DaiNatasha M Rogers
Aug 8, 2020·Nature Reviews. Gastroenterology & Hepatology·Angus W ThomsonAlberto Sanchez-Fueyo

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Methods Mentioned

BETA
flow cytometry
biopsy

Software Mentioned

enprEMA
Trucount

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