PMID: 6973609Aug 1, 1981Paper

Immune networks. Frequencies of antibody- and idiotype-producing B cell clones in various steady states

The Journal of Experimental Medicine
R R BernabéP A Cazenave

Abstract

In limiting dilution analysis, the absolute frequencies of lipopolysaccharide-reactive B cell precursors producing anti-trinitrophenyl antibodies or the MOPC460 idiotype were studied in BALB/c mice, either normal, or immunized with antigen (Ab1), the idiotype (Ab2), or a monoclonal anti-idiotype antibody (Ab3). Anti-idiotype immunity results in the suppression of the B cell precursors for the relevant idiotype, and anti-(anti-idiotype) immunity leads to a 10-fold increase in precursor B cell frequencies, with a comparatively lower increase in antibody-producing precursors. The findings can only be explained by variations in the composition of the B cell compartment in the various immune states.

References

Nov 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·P A Cazenave
Nov 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·J UrbainC Collignon
Aug 1, 1976·European Journal of Immunology·E GronowiczF Melchers
Jun 1, 1975·The Journal of Experimental Medicine·N Sakato, H N Eisen

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Citations

May 16, 1998·European Journal of Immunology·A NobregaA Coutinho
Jan 1, 1989·Bulletin of Mathematical Biology·R J De Boer, P Hogeweg
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·C MartinzA Coutinho
Jul 1, 1982·The Journal of Experimental Medicine·D PrimiP A Cazenave
Mar 9, 1999·International Immunology·R VasconcellosJ Demengeot
Jan 1, 1989·Bulletin of Mathematical Biology·R J De Boer, P Hogeweg
Jun 1, 1994·European Journal of Immunology·A GrandienA Coutinho
Nov 1, 1986·European Journal of Immunology·C MartinezA Coutinho
Aug 1, 1990·European Journal of Immunology·T Mota-SantosP A Cazenave

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