Immune Parameters That Distinguish Multiple Sclerosis Patients from Patients with Other Neurological Disorders at Presentation

PloS One
Athanasia MouzakiPanagiotis Papathanasopoulos

Abstract

Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system. Effector T helper cells, mainly Th1 and Th17, cytotoxic T-cells, B-cells, macrophages, microglia, and the cytokines they secrete, are implicated in the initiation and maintenance of a deregulated immune response to myelin antigens and the ensuing immune-mediated demyelination. In this study, we investigated whether signature cytokines exist in MS patients at presentation to gain an insight into the underlying immunopathogenic processes at the early stage of the disease. We collected serum and cerebrospinal fluid (CSF) samples from 123 patients at presentation, eventually diagnosed with MS or non-inflammatory (NIND) or inflammatory neurological diseases (IND) or symptomatic controls (SC). The levels of cytokines IFN-γ, TNF-α, TGF-β1, IL-2, IL-4, IL-6, IL-10 and IL-17 were measured, and cytokine ratios, such as Th1/Th2, Th1/Th17, and Type-1/Type-2, were calculated. All parameters were tested for their correlations with the intrathecal IgG synthesis. Cytokine levels in CSF were lower than in serum in all the patients, with the exception of IL-6. Serum or CSF cytokine levels of MS patients did not differ significantly from NIND or SC, w...Continue Reading

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Citations

Mar 22, 2016·Mediators of Inflammation·Michal A Rahat, Jivan Shakya
Apr 11, 2017·Neurologia i neurochirurgia polska·Vitalie VăcăraşAnca Dana Buzoianu
Apr 10, 2021·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·E Yu SkripchenkoA A Vilnitz

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Methods Mentioned

BETA
ELISA
ESR

Software Mentioned

CurveExpert
BioMS
GraphPad Prism
FlowJo
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