PMID: 16522254Mar 9, 2006Paper

Immune pathogenesis of pediatric HIV-1 infection

Current HIV/AIDS Reports
Caroline T Tiemessen, Louise Kuhn

Abstract

Vertical exposure to HIV occurs at a time when functional capacity of the infant's immune system is attenuated through immaturity. Immune response capability is rooted in host genetic makeup, and the broad and fine specificity of innate and adaptive immune responses, respectively, shape the outcomes of HIV encounter in some instances and imprint viral changes through selective immune pressure in others. Findings from recent studies have profound implications for understanding immune pathogenesis of pediatric HIV infection and, in particular, highlight the importance of host genetics of both mother and child in determining whether an exposed child acquires HIV infection or not and, if infected, the rate of disease progression. This review focuses on the key host molecules, the CC chemokine CCL3 and HLA, which have taken center stage in these new developments.

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Citations

Feb 17, 2007·Nature Immunology·Caroline T Tiemessen, Louise Kuhn
Jul 27, 2006·Proceedings of the National Academy of Sciences of the United States of America·Vasudha SundaravaradanNafees Ahmad
Aug 23, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Josiane WarszawskiStéphane Blanche
Nov 28, 2013·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Flávia Jacqueline AlmeidaLuis Fernando de Macedo Brígido
Nov 12, 2013·Journal of Chemical Information and Modeling·Qi ChenDongqing Wei
Sep 15, 2016·Expert Review of Clinical Pharmacology·Baralee PunyawudhoKiat Ruxrungtham
May 9, 2006·Nature Structural & Molecular Biology·Tiffiney Roberts HartmanKathleen Boris-Lawrie
Aug 14, 2018·Tropical Medicine & International Health : TM & IH·Ditte SteinicheUNKNOWN Bissau HIV Cohort Study Group
Apr 18, 2009·Current Opinion in HIV and AIDS·Jan WalterGrace M Aldrovandi
Apr 8, 2014·Journal of Perinatal Medicine·Yen-Chang Lee, Syh-Jae Lin
Jun 19, 2019·American Journal of Epidemiology·Nicky J MehtaniWilliam J Moss
Jun 3, 2021·Journal of Clinical Medicine·Stephanie ShiauLouise Kuhn

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