Immune persistence after hepatitis B vaccination in infancy - Fact or fancy?

Human Vaccines & Immunotherapeutics
Terence T Lao

Abstract

The hepatitis B vaccine has been introduced for more than 3 decades. In Hong Kong, excellent vaccine coverage through an efficient public health care system, together with supplemental programmes and easy availability of the vaccine, meant that most young pregnant women, and university students at entrance, should have been protected. Yet significant correlations in the prevalence of HBV infection with age were found in these groups of subjects, increasing from low to high endemicity rates from late teenage to the early twenties. This can only be attributed to vaccine failure, and there is cumulating evidence that several factors are involved, including the failure to respond to a primary series of hepatitis B vaccination in infancy, the waning of antibody titer with age, and loss of anamnestic response in a significant portion of the vaccinees. The duration of protection conferred by hepatitis B vaccination in infancy should be re-examined and remedial measures undertaken if its long term protection is found to be insufficient. Otherwise, the efforts to control HBV infection, especially in high endemicity regions, with universal vaccination in infancy would be rendered futile.

References

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Citations

Dec 3, 2016·Human Vaccines & Immunotherapeutics·Andrea Trevisan
Jul 5, 2019·Alimentary Pharmacology & Therapeutics·Kai-Chi ChangUNKNOWN Taiwan Study Group for the Prevention of Mother-to-Infant Transmission of HBV (PreMIT study)
Jul 29, 2017·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Mayumi FujimotoJunko Tanaka
Aug 24, 2018·Scientific Reports·Sajid MahmoodTahir Mehmood Khan
Oct 31, 2017·Human Vaccines & Immunotherapeutics·Hong Zhao, Yi-Hua Zhou
Jan 18, 2020·Journal of Korean Medical Science·Yoonjung KimJung Gyu Lee
Apr 20, 2021·Medical Journal, Armed Forces India·Dharmendra KumarReema Mukerjee

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