Immune profile and mitotic index of metastatic melanoma lesions enhance clinical staging in predicting patient survival.

Proceedings of the National Academy of Sciences of the United States of America
Dusan BogunovicNina Bhardwaj

Abstract

Although remission rates for metastatic melanoma are generally very poor, some patients can survive for prolonged periods following metastasis. We used gene expression profiling, mitotic index (MI), and quantification of tumor infiltrating leukocytes (TILs) and CD3+ cells in metastatic lesions to search for a molecular basis for this observation and to develop improved methods for predicting patient survival. We identified a group of 266 genes associated with postrecurrence survival. Genes positively associated with survival were predominantly immune response related (e.g., ICOS, CD3d, ZAP70, TRAT1, TARP, GZMK, LCK, CD2, CXCL13, CCL19, CCR7, VCAM1) while genes negatively associated with survival were cell proliferation related (e.g., PDE4D, CDK2, GREF1, NUSAP1, SPC24). Furthermore, any of the 4 parameters (prevalidated gene expression signature, TILs, CD3, and in particular MI) improved the ability of Tumor, Node, Metastasis (TNM) staging to predict postrecurrence survival; MI was the most significant contributor (HR = 2.13, P = 0.0008). An immune response gene expression signature and presence of TILs and CD3+ cells signify immune surveillance as a mechanism for prolonged survival in these patients and indicate improved patien...Continue Reading

Associated Clinical Trials

References

Jan 5, 2000·Proceedings of the National Academy of Sciences of the United States of America·M P BrownD Haussler
Apr 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·V G TusherG Chu
Nov 19, 2004·The New England Journal of Medicine·Sandeep S DaveLouis M Staudt
Feb 22, 2005·Lancet·John F ThompsonRichard F Kefford
Apr 19, 2005·Proceedings of the National Academy of Sciences of the United States of America·Christopher HaqqMohammed Kashani-Sabet
Dec 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·Eiichi SatoKunle Odunsi
Feb 6, 2007·American Journal of Clinical Pathology·Maria Gallego Attis, Robin T Vollmer
Feb 10, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jochen JaegerManfred Kunz
Feb 23, 2007·Nature·Vanessa Gray-SchopferRichard Marais
Apr 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Leslie A FecherRhoda M Alani
Jan 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles M Balch, Seng-Jaw Soong
Apr 4, 2008·Nature·Laura J van't Veer, René Bernards
May 30, 2008·Frontiers in Bioscience : a Journal and Virtual Library·Ken Mills
Jun 10, 2008·Recent Patents on Anti-cancer Drug Discovery·Zeina A Nahleh
Aug 14, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Thomas JohnJonathan S Cebon
Feb 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Hong ChenPadmanee Sharma

❮ Previous
Next ❯

Citations

Jan 12, 2011·Cancer Immunology, Immunotherapy : CII·Mary L Disis
Dec 8, 2011·Cancer Immunology, Immunotherapy : CII·Rui-Ru JiVafa Shahabi
Apr 11, 2012·Cancer Immunology, Immunotherapy : CII·Gwendoline Rahir, Muriel Moser
Mar 20, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Michelle W MaFarbod Darvishian
Mar 24, 2010·Proceedings of the National Academy of Sciences of the United States of America·Rajmohan Murali, Richard A Scolyer
Oct 5, 2010·Pigment Cell & Melanoma Research·Amy E RoseIman Osman
Oct 29, 2010·Science Translational Medicine·Johan Garaude, J Magarian Blander
Jun 8, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Katja HarbstGöran Jönsson
Apr 2, 2011·BMC Medical Genomics·Trevor ClancyEivind Hovig
Aug 10, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Edward Cha, Lawrence Fong
May 23, 2012·PLoS Computational Biology·Christof WinterRobert Grützmann
Apr 27, 2012·PloS One·Li WangCristin G Print
Jun 14, 2012·PloS One·Manfred SchartlSvenja Meierjohann
May 8, 2013·Future Oncology·Ewa AladowiczLuisa Lanfrancone
Feb 4, 2014·Virchows Archiv : an International Journal of Pathology·Mario Mandalà, Daniela Massi
Dec 21, 2012·Briefings in Bioinformatics·Janine RoyMichael Schroeder
Apr 14, 2012·Journal of Biomedicine & Biotechnology·Daria CapeceEdoardo Alesse
May 10, 2011·Cancer Immunology, Immunotherapy : CII·Arcadi CipponiPierre G Coulie
Dec 2, 2015·Expert Review of Molecular Diagnostics·Mona FothWilliam M Gallagher
Apr 27, 2010·Expert Opinion on Biological Therapy·Theresa L Whiteside
Oct 29, 2014·Journal of Translational Medicine·Paolo A AsciertoMagdalena Thurin
Jan 29, 2016·Journal of the National Cancer Institute·Behrouz ZandAnil K Sood
Nov 18, 2015·Proceedings of the National Academy of Sciences of the United States of America·Antoine TanneBenjamin D Greenbaum
Oct 4, 2012·Trends in Immunology·Jianjun GaoPatrick Hwu
May 5, 2012·The Lancet Oncology·Elisa TremantePatrizio Giacomini
Apr 12, 2012·Drug Discovery Today·Emily C Shaw, Peter W M Johnson
Feb 2, 2010·Current Opinion in Immunology·Tyler R SimpsonJames P Allison
Feb 2, 2016·The Journal of Investigative Dermatology·Nicolas JacquelotLaurence Zitvogel
Oct 1, 2011·The Journal of Investigative Dermatology·Sarah-Jane SchrammGraham J Mann
Jun 9, 2015·Molecular Cell·Chiara VardabassoEmily Bernstein

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.