Immune profiling in patients with recurrent miscarriage

Journal of Reproductive Immunology
R J KuonBettina Toth

Abstract

The central role of the maternal immune system for successful and disturbed pregnancies such as recurrent miscarriage (RM) is apparent. Recent studies have increased understanding of the complex interaction of the different immunological players and the adaptation of the maternal immune system to the semi-allogeneic embryo. There is growing evidence for immunological abnormalities in RM patients, including autoimmune and allogeneic factors. However, the question remains unsolved whether these changes represent the cause or the consequence of RM. As in half of the RM patients the underlying mechanism remains unknown, further diagnostic methods are urgently needed. Within this review we summarize (recent) literature on the immunological diagnosis in RM patients to find out current trends and to identify potential targets of therapy. As the exact mechanisms of feto-maternal tolerance have not yet been determined we suggest that the immunological diagnosis should be implemented only in well-designed clinical trials in specialized centers to establish a standardized immunological work-up in RM patients.

References

May 18, 1985·British Medical Journal·F G McDonald, M M Ferguson
Feb 5, 2000·European Journal of Obstetrics, Gynecology, and Reproductive Biology·G PorcuB Blanc
Jul 11, 2002·Journal of Reproductive Immunology·Sulani S SouzaJulio C Voltarelli
Sep 5, 2002·Nature Reviews. Immunology·Ashley Moffett-King
Feb 7, 2004·BMJ : British Medical Journal·Polly J BingleyUNKNOWN Avon Longitudinal Study of Parents and Children Study Team
Oct 16, 2004·Lupus·H Carp
Mar 12, 2005·Human Reproduction·Raj RaiGeoffrey Trew
Jun 30, 2005·BMJ : British Medical Journal·Maureen T M FranssenMariette Goddijn
Nov 1, 2005·Current Opinion in Obstetrics & Gynecology·Belinda CarringtonLesley Regan
Feb 3, 2006·American Journal of Reproductive Immunology : AJRI·Daniel BustosNorma Prigoshin
Jul 4, 2006·Journal of Leukocyte Biology·Gendie E LashJudith N Bulmer
Aug 22, 2006·Scandinavian Journal of Immunology·B T Kurien, R H Scofield
Nov 2, 2006·American Journal of Reproductive Immunology : AJRI·Yehuda ShoenfeldPer Luigi Meroni
Nov 15, 2006·Immunological Reviews·B Anne CroyChandrakant Tayade
Jan 16, 2007·American Journal of Reproductive Immunology : AJRI·Charles L SentmanMikael Eriksson
Sep 22, 2007·Fetal and Pediatric Pathology·Faruk HadziselimovicMauro Buser
Feb 21, 2008·Reproductive Biomedicine Online·Angela SantoniAngela Gismondi
Mar 28, 2008·Digestive Diseases and Sciences·Antonio TursiWalter Elisei
Aug 2, 2008·Obstetrics and Gynecology·Marc A RodgerIan Greer
Dec 17, 2008·Reproductive Biomedicine Online·Qiong WangShu-Zhong Yao
Feb 27, 2010·Journal of Reproductive Immunology·Bettina TothAntonis Makrigiannakis
May 12, 2010·American Journal of Reproductive Immunology : AJRI·Shigeru SaitoMika Ito
Dec 7, 2010·Inflammopharmacology·Graham R V Hughes
Feb 22, 2011·Journal of Reproductive Immunology·Gendie E Lash, Judith N Bulmer
Mar 1, 2012·American Journal of Reproductive Immunology : AJRI·Akitoshi NakashimaShigeru Saito
Mar 3, 2012·American Journal of Reproductive Immunology : AJRI·Sung Ki LeeJoanne Kwak-Kim
Mar 3, 2012·American Journal of Reproductive Immunology : AJRI·Kenneth D BeamanAlice Gilman-Sachs

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Citations

Nov 5, 2016·The Journal of Endocrinology·S P SivarajasingamM R Johnson
Oct 31, 2017·American Journal of Reproductive Immunology : AJRI·Fanfan LiDongrui Deng
Jun 16, 2018·American Journal of Reproductive Immunology : AJRI·Su LiuYong Zeng
Nov 5, 2019·American Journal of Reproductive Immunology : AJRI·Tino W SanchezEugenia Mata-Greenwood
Nov 5, 2019·American Journal of Reproductive Immunology : AJRI·Luiza Oliveira PerucciAndré Talvani
Oct 4, 2017·BJOG : an International Journal of Obstetrics and Gynaecology·W BahiaW Y Almawi
Jan 31, 2017·American Journal of Reproductive Immunology : AJRI·Katrin Hefler-FrischmuthChristoph Grimm
Jun 9, 2021·Immunity, Inflammation and Disease·Sudong LiuRuiqiang Weng

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