Immune Profiling of Cancer Patients Treated with Immunotherapy: Advances and Challenges

Biomedicines
Lorenzo Pilla, Cristina Maccalli

Abstract

The recent advances in immunotherapy and the availability of novel drugs to target the tumor microenvironment have dramatically changed the paradigm of cancer treatment. Nevertheless, a significant proportion of cancer patients are unresponsive or develop resistance to these treatments. With the aim to increase the clinical efficacy of immunotherapy, combinations of agents and standard therapies with complementary actions have been developed mostly on an empirical base, since their mechanisms of actions are not yet fully dissected. The characterization of immune responsiveness and its monitoring along with the treatment of cancer patients with immunotherapy can provide insights into the mechanisms of action of these therapeutic regimens and contribute to the optimization of patients' stratification and of combination strategies and to the prediction of treatment-related toxicities. Thus far, none of the immunomonitoring strategies has been validated for routine clinical practice. Moreover, it is becoming clear that the genomic and molecular make-up of tumors and of the infiltrating immune system represent important determinants of the clinical responses to immunotherapy. This review provides an overview of different approaches ...Continue Reading

References

May 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E TartourW H Fridman
Jun 27, 2003·Proceedings of the National Academy of Sciences of the United States of America·Giao Q PhanSteven A Rosenberg
Mar 16, 2005·Current Opinion in Immunology·Thomas Blankenstein
Aug 10, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Peter AttiaSteven A Rosenberg
Nov 23, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ajay V MakerSteven A Rosenberg
Jun 7, 2006·Proceedings of the National Academy of Sciences of the United States of America·Masahisa JinushiGlenn Dranoff
Jun 27, 2006·Journal of Immunotherapy·Ajay V MakerSteven A Rosenberg
Sep 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Chrystal M PaulosNicholas P Restifo
Nov 21, 2007·Nature·Catherine M KoebelRobert D Schreiber
Aug 14, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Cédric MénardCaroline Robert
Sep 27, 2008·Proceedings of the National Academy of Sciences of the United States of America·Chrysoula I LiakouPadmanee Sharma
Dec 18, 2008·Cancer Immunology, Immunotherapy : CII·Cristina MaccalliGiorgio Parmiani
Mar 5, 2009·Cancer Research·Matthieu CamusJérôme Galon
Apr 15, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marianna SabatinoHoward L Kaufman
May 19, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robert H VonderheideSusan M Domchek
Jan 20, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bernhard MlecnikJérôme Galon
Apr 5, 2011·Seminars in Immunopathology·Gabriela BindeaJérôme Galon
Apr 6, 2011·Cancer Immunology, Immunotherapy : CII·Jianda YuanJedd D Wolchok
Sep 22, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jianda YuanSacha Gnjatic
Oct 25, 2011·Nature Reviews. Cancer·Padmanee SharmaJames P Allison
May 12, 2012·CA: a Cancer Journal for Clinicians·John M KirkwoodSoldano Ferrone
May 23, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey S WeberAxel Hauschild
Jun 5, 2012·The New England Journal of Medicine·Suzanne L TopalianMario Sznol
Jun 5, 2012·The New England Journal of Medicine·Julie R BrahmerJon M Wigginton
Jul 12, 2012·Nature Biotechnology·Sean C Bendall, Garry P Nolan
Nov 22, 2013·Methods in Molecular Biology·Lisa H Butterfield, Mary Jo Buffo
Dec 11, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Benjamin WeideGraham Pawelec
Dec 21, 2013·Cancer Immunology, Immunotherapy : CII·Christiane MeyerDaniel E Speiser
Mar 13, 2014·Cancer Immunology, Immunotherapy : CII·Sander KeldermanChristian U Blank
Mar 19, 2014·European Journal of Cell Biology·Annette PaschenDirk Schadendorf
Jun 24, 2014·Nature Biotechnology·Arnold HanMark M Davis
Jun 27, 2014·Cancer Immunology, Immunotherapy : CII·Yago Pico de CoañaRolf Kiessling
Jul 23, 2014·Oncoimmunology·Aroa Baragaño RanerosCarlos López-Larrea
Aug 29, 2014·Cancer Immunology, Immunotherapy : CII·Zlatko TrajanoskiPaolo Dellabona
Sep 19, 2014·Science Translational Medicine·Pia KvistborgTon N Schumacher

❮ Previous
Next ❯

Citations

Dec 4, 2020·Journal for Immunotherapy of Cancer·Siwen Hu-LieskovanHolden T Maecker
May 18, 2021·Frontiers in Molecular Biosciences·Sharia HernandezEdwin Roger Parra

❮ Previous
Next ❯

Methods Mentioned

BETA
Whole-Genome

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.