Immune Profiling to Determine Early Disease Trajectories Associated With Coronavirus Disease 2019 Mortality Rate: A Substudy from the ACTT-1 Trial.

The Journal of Infectious Diseases
Joshua M ThiedeTyler D Bold


Coronavirus disease 2019 (COVID-19) outcomes are linked to host immune responses and may be affected by antiviral therapy. We investigated antibody and cytokine responses in ACTT-1 study participants enrolled at our center. We studied serum specimens from 19 hospitalized adults with COVID-19 randomized to treatment with remdesivir or placebo. We assessed severe acute respiratory syndrome coronavirus 2 antibody responses and identified cytokine signatures, using hierarchical clustering. We identified no clear immunologic trends attributable to remdesivir treatment. Seven participants were initially seronegative at study enrollment, and all 4 deaths occurred in this group with more recent symptom onset. We identified 3 dominant cytokine signatures, demonstrating different disease trajectories.


Apr 15, 2020·Cell Host & Microbe·Xuping XiePei-Yong Shi
May 1, 2020·Nature Medicine·Quan-Xin LongAi-Long Huang
May 18, 2020·Science·Florian Krammer, Viviana Simon
May 24, 2020·The New England Journal of Medicine·John H BeigelUNKNOWN ACTT-1 Study Group Members
Jul 28, 2020·Nature·Carolina LucasAkiko Iwasaki
Aug 15, 2020·Nature Communications·Antonio E MuruatoPei-Yong Shi
Aug 19, 2020·Nature Medicine·Adam G LaingAdrian C Hayday
Aug 26, 2020·Nature Medicine·Diane Marie Del ValleSacha Gnjatic
Aug 26, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lili RenBin Cao
Aug 28, 2020·Nature·Takehiro TakahashiAkiko Iwasaki
Nov 11, 2020·Cell·Yuezhou ChenDuane R Wesemann

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