Immune Protection against Virus Challenge in Aging Mice Is Not Affected by Latent Herpesviral Infections

Journal of Virology
Thomas F MaranduLuka Cicin-Sain

Abstract

Latent herpesvirus infections alter immune homeostasis. To understand if this results in aging-related loss of immune protection against emerging infections, we challenged old mice carrying latent mouse cytomegalovirus (CMV), herpes simplex virus 1 (HSV-1), and/or murine gammaherpesvirus 68 (MHV-68) with influenza virus, West Nile virus (WNV), or vesicular stomatitis virus (VSV). We observed no increase in mortality or weight loss compared to results seen with herpesvirus-negative counterparts and a relative but not absolute reduction in CD8 responses to acute infections. Therefore, the presence of herpesviruses does not appear to increase susceptibility to emerging infections in aging patients.

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Citations

Sep 11, 2016·Clinical and Experimental Immunology·R R Montgomery
Jun 26, 2017·GeroScience·Sarah E JacksonMark R Wills
Dec 16, 2017·Nature Immunology·Janko Nikolich-Žugich
Oct 20, 2019·Vaccines·Mario Alberto Ynga-DurandLuka Cicin-Sain
Jul 4, 2018·Proceedings of the National Academy of Sciences of the United States of America·Megan J SmitheyJanko Nikolich-Žugich
Sep 11, 2020·The Journal of Infectious Diseases·Janko Nikolich-Žugich
Oct 22, 2019·European Journal of Immunology·Andrea CossarizzaArturo Zychlinsky
Mar 13, 2020·GeroScience·Janko Nikolich-ŽugichNiels Lemmermann
Apr 21, 2019·Medical Microbiology and Immunology·Mladen JergovićJanko Nikolich-Žugich
Oct 12, 2020·Current Opinion in Virology·Leila Abassi, Luka Cicin-Sain
Nov 8, 2020·Current Opinion in Virology·Janko Nikolich-ŽugichMakiko Watanabe

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