Immune protection induced on day 10 following administration of the 2009 A/H1N1 pandemic influenza vaccine

PloS One
Yizhuo SunBing Sun

Abstract

The 2009 swine-origin influenza virus (S-OIV) H1N1 pandemic has caused more than 18,000 deaths worldwide. Vaccines against the 2009 A/H1N1 influenza virus are useful for preventing infection and controlling the pandemic. The kinetics of the immune response following vaccination with the 2009 A/H1N1 influenza vaccine need further investigation. 58 volunteers were vaccinated with a 2009 A/H1N1 pandemic influenza monovalent split-virus vaccine (15 µg, single-dose). The sera were collected before Day 0 (pre-vaccination) and on Days 3, 5, 10, 14, 21, 30, 45 and 60 post vaccination. Specific antibody responses induced by the vaccination were analyzed using hemagglutination inhibition (HI) assay and enzyme-linked immunosorbent assay (ELISA). After administration of the 2009 A/H1N1 influenza vaccine, specific and protective antibody response with a major subtype of IgG was sufficiently developed as early as Day 10 (seroprotection rate: 93%). This specific antibody response could maintain for at least 60 days without significant reduction. Antibody response induced by the 2009 A/H1N1 influenza vaccine could not render protection against seasonal H1N1 influenza (seroconversion rate: 3% on Day 21). However, volunteers with higher pre-exis...Continue Reading

References

May 9, 2009·The New England Journal of Medicine·Fatimah S DawoodTimothy M Uyeki
Jun 16, 2009·Nature·Gabriele NeumannYoshihiro Kawaoka
Jun 23, 2009·Science·Jon Cohen, Martin Enserink
Sep 12, 2009·The New England Journal of Medicine·Kathy HancockJacqueline M Katz
Sep 12, 2009·The New England Journal of Medicine·Tristan W ClarkIain Stephenson
Sep 12, 2009·The New England Journal of Medicine·Michael E GreenbergRussell L Basser
Oct 23, 2009·The New England Journal of Medicine·Feng-Cai ZhuJing-Shan Zheng
Nov 7, 2009·AACN Advanced Critical Care·Nancy BlakeDawn England
Apr 8, 2010·Science Translational Medicine·Giuseppe Del GiudiceRino Rappuoli

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
ELISAs

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