Immune Protection of Stem Cell-Derived Islet Cell Therapy for Treating Diabetes.

Frontiers in Endocrinology
Meghan Tahbaz, Eiji Yoshihara


Insulin injection is currently the main therapy for type 1 diabetes (T1D) or late stage of severe type 2 diabetes (T2D). Human pancreatic islet transplantation confers a significant improvement in glycemic control and prevents life-threatening severe hypoglycemia in T1D patients. However, the shortage of cadaveric human islets limits their therapeutic potential. In addition, chronic immunosuppression, which is required to avoid rejection of transplanted islets, is associated with severe complications, such as an increased risk of malignancies and infections. Thus, there is a significant need for novel approaches to the large-scale generation of functional human islets protected from autoimmune rejection in order to ensure durable graft acceptance without immunosuppression. An important step in addressing this need is to strengthen our understanding of transplant immune tolerance mechanisms for both graft rejection and autoimmune rejection. Engineering of functional human pancreatic islets that can avoid attacks from host immune cells would provide an alternative safe resource for transplantation therapy. Human pluripotent stem cells (hPSCs) offer a potentially limitless supply of cells because of their self-renewal ability and ...Continue Reading


Mar 1, 1990·Trends in Biotechnology·O Smidsrød, G Skjåk-Braek
Feb 1, 1992·Transplantation·C RicordiD H Mintz
Dec 1, 1991·Diabetes·C Hellerström, I Swenne
Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·P RorsmanP O Berggren
May 29, 1970·Science· Espinosa de los MonterosJ Steinke
Jul 25, 1997·The Journal of Biological Chemistry·F SchuitM Prentki
Nov 6, 1998·Science·J A ThomsonJ M Jones
Feb 4, 1999·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·S F JosephsR C Johnson
Sep 10, 2002·Proceedings of the National Academy of Sciences of the United States of America·Yoshiko IwaiNagahiro Minato
Jul 9, 2003·The Journal of Experimental Medicine·Mohammed Javeed I AnsariMohamed H Sayegh
Feb 14, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Bernhard J HeringJeffrey A Bluestone
Aug 18, 2004·The Journal of Surgical Research·Martijn de GrootReinout van Schilfgaarde
Feb 17, 2005·JAMA : the Journal of the American Medical Association·Bernhard J HeringDavid E R Sutherland
Feb 17, 2005·Transplantation·Abdulkadir OmerGordon C Weir
Aug 27, 2005·Diabetes·Monica TetaJake A Kushner
Nov 1, 2005·Nature Biotechnology·Kevin A D'AmourEmmanuel E Baetge
Jan 26, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D YinA S Chong
Apr 12, 2006·The Journal of Experimental Medicine·Mary E KeirArlene H Sharpe
Oct 21, 2006·Nature Biotechnology·Kevin A D'AmourEmmanuel E Baetge
Oct 27, 2007·Expert Opinion on Biological Therapy·Simona MarzoratiCamillo Ricordi
Dec 7, 2007·Biochemical and Biophysical Research Communications·Young Min ChoHong Kyu Lee
Mar 20, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Titte R Srinivas, Herwig-Ulf Meier-Kriesche
Jul 10, 2008·Nature Biotechnology·Norio NakatsujiKatsushi Tokunaga
Aug 30, 2008·Journal of Molecular Endocrinology·Cyrus C MartinRichard M O'Brien
Dec 2, 2008·The Journal of Surgical Research·Niteen TapuriaBrian R Davidson
Mar 17, 2009·Nature Chemical Biology·Shuibing ChenDouglas Melton
Feb 16, 2010·Nature Reviews. Immunology·Margarida Saraiva, Anne O'Garra

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Autoimmune Disease Therapy

In autoimmune diseases, the immune system responds and attacks self-antigens and damages or impairs the function of the tissues. The treatment for autoimmune diseases often involves immunosuppressive agents, but newer treatments are being investigated. Discover the latest research on autoimmune disease therapy here.

Related Papers

Advances in Experimental Medicine and Biology
Yuji TeramuraBo Nilsson
The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
Marcela BrissovaRebecca L Hull
Advances in Experimental Medicine and Biology
M H AbdulredaPer-Olof Berggren
Clinical Medicine Insights. Endocrinology and Diabetes
Varun PathakReinhold J Medina
© 2021 Meta ULC. All rights reserved