PMID: 6163328Jan 1, 1981Paper

Immune reactions and long-term therapy with human leukocyte interferon

Acta Medica Scandinavica
S IngimarssonH Strander

Abstract

Twenty patients with osteosarcoma were treated with exogenous human leukocyte interferon for periods ranging from 6 to 18 months. Eleven of them remained free from detectable tumour growth during this treatment. Blood samples from all patients were tested for antibodies against interferon and against impurities in the interferon preparations. No patient developed detectable levels of neutralizing antibodies against interferon. All patients formed antibodies against contaminants in the concentrated crude interferon and the partially purified interferon preparation which had been used for treatment.

References

Nov 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·K PauckerE Törmä
Feb 3, 1979·Lancet·H MellstedtH Strander
Oct 1, 1979·The Journal of Infectious Diseases·S IngimarssonH Strander
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Jan 1, 1949·Journal of General Microbiology·F FULTON, K R DUMBELL

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Citations

Nov 1, 1988·Acta Psychiatrica Scandinavica·A NiiranenK Cantell
Jan 1, 1984·Critical Reviews in Clinical Laboratory Sciences·W J Richtsmeier
Sep 24, 1982·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·H Strander, S Einhorn
Dec 1, 1986·Journal of Interferon Research·A V Palleroni, P W Trown
Sep 1, 1995·Medicinal Research Reviews·G C ViscomiS Silvestri
Jan 15, 1983·Lancet·P W TrownJ U Gutterman

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