PMID: 3493070Jan 1, 1987

Immune reactivity in SL2 lymphoma-bearing mice compared with SL2-immunized mice

Cancer Immunology, Immunotherapy : CII
R A De WegerW Den Otter


We have studied the rather paradoxical phenomenon of the growth of an antigenic tumor in an immunocomponent host. This phenomenon was studied by comparing the lymphocyte reactivity and the macrophage cytotoxicity, during SL2 growth in DBA/2 mice (SL2-bearing mice) and in DBA/2 mice immunized against SL2 tumor cells (SL2-immune mice). Immune mice rejected a challenge of tumor cells. The immune T-lymphocytes rendered macrophages cytotoxic (arming) and were able to transfer tumor resistance to naive animals. Nonimmunized mice did not reject a challenge of SL2 cells. In these tumor-bearing mice various forms of immune reactivity were tested. Lymphocytes with the capacity to arm macrophages could not be found in the lymphoid organs. However, lymphocytes isolated from the tissue directly surrounding the subcutaneous SL2 tumor could arm macrophages in vitro. Shortly after subcutaneous tumor grafting cytotoxic macrophages were found in the peritoneal cavity. In the serum macrophage arming factors were detected that rendered macrophages cytotoxic in vitro. This cytotoxicity of the peritoneal macrophages and the presence of macrophage arming factors in the serum showed a similar biphasic pattern. The first phase of cytotoxicity between d...Continue Reading


Jan 1, 1989·Cancer Immunology, Immunotherapy : CII·R A De WegerW Den Otter
Jan 1, 1990·Cancer Immunology, Immunotherapy : CII·D CharaciejusW Den Otter
Jan 1, 1993·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·D Lovens-De GraefN Schaaf-Lafontaine
Jan 5, 2005·Comptes rendus biologies·Anastasios Matzavinos, Mark A J Chaplain
Apr 2, 2003·Cancer Immunology, Immunotherapy : CII·Agnieszka MasztalerzLinda A Everse

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