Immune reactivity of the purified hemagglutinin of measles virus.

Infection and Immunity
W J BelliniH F McFarland

Abstract

The role of the immune response to measles virus in acute infection or in disease states associated with this virus is of major interest. The viral genome-specified surface antigens of measles, the hemagglutinin and fusion proteins, are likely to be of paramount importance with respect to the host immune response to the virus. This report describes initial studies aimed at assessing the immune response to the major surface glycoprotein, the hemagglutinin. This antigen was purified by affinity chromatography, using a monoclonal anti-hemagglutinin immobilized on Sepharose. The purified protein retained biological activity in hemagglutination assays. This activity could be specifically inhibited with a human antimeasles serum and with monoclonal antibody to the hemagglutinin. Lymphocytes from individuals known to proliferate to measles-infected monolayers also proliferated to the purified hemagglutinin. Thus, the immune-response to measles virus is, in part, directed to this surface antigen.

Citations

Dec 14, 2002·Viral Immunology·Fabienne B BoucheClaude P Muller
Aug 1, 1989·Scandinavian Journal of Immunology·M J MäkeläT F Wild
Apr 11, 2006·Clinical and Vaccine Immunology : CVI·Sallie R PermarNorman L Letvin
May 1, 1989·Scandinavian Journal of Immunology·M J MäkeläA A Salmi
Jan 1, 1984·Annals of the New York Academy of Sciences·J R RichertD E McFarlin
Jan 1, 1983·Archives of Virology·W J BelliniD E McFarlin
Mar 1, 1984·Journal of Virology·J W RoseH F McFarland
Aug 8, 2006·Journal of Clinical Microbiology·Marcelo H ArgüellesGraciela Glikmann

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.