Immune receptor expressed on myeloid cells 1 (IREM-1) inhibits B cell activation factor (BAFF)-mediated inflammatory regulation of THP-1 cells through modulation of the activities of extracellular regulated kinase (ERK).

Clinical and Experimental Immunology
S-M LeeW-H Lee

Abstract

The immune receptor expressed on myeloid cells 1 (IREM-1) has been known to regulate the activities of myeloid cells through its immunoreceptor tyrosine-based inhibition motifs (ITIMs) in its intracellular region. In order to investigate its effect on macrophage activation, a human macrophage cell line (THP-1) was tested after stimulation of its membrane-bound form of B cell activation factor (BAFF), which has been shown to modulate inflammatory activities through induction of proinflammatory mediator expression and suppression of phagocytosis. IREM-1-specific monoclonal antibodies detected the expression of high levels of IREM-1 in THP-1 cells. Cross-linking of IREM-1 with these antibodies resulted in the blockage of the BAFF-mediated expression of interleukin (IL)-8 and matrix metalloproteinase (MMP)-9 through inhibition of the activation of extracellular regulated kinase (ERK) and phosphorylation/degradation of IκB. Furthermore, cross-linking of IREM-1 also reversed the BAFF-mediated inhibition of phagocytosis. In order to demonstrate the role of ITIM in the IREM-1-mediated suppression of BAFF signalling, a decapeptide containing YADL (an ITIM in IREM-1) was fused with HIV-TAT(48-57) which was required for the internalizatio...Continue Reading

References

Nov 13, 2002·Annual Review of Immunology·Fabienne MackayJeffrey Browning
Sep 17, 2003·The Journal of Experimental Medicine·Leonid GorelikMartin L Scott
Nov 19, 2004·European Journal of Immunology·Damiana Alvarez-ErricoMiguel López-Botet
Apr 15, 2005·Molecular Immunology·Lai Guan NgFabienne Mackay
May 12, 2005·Current Opinion in Immunology·Pascal Schneider
Feb 14, 2006·Nature Reviews. Drug Discovery·Stacey R DillonAnne J Novak
Feb 21, 2006·Biochemical and Biophysical Research Communications·Amy O HardinB Keith English
Jan 5, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Damiana Alvarez-ErricoMiguel López-Botet
Dec 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ismail CanAkira Shibuya
Mar 18, 2009·Immunological Reviews·Ulrike Lorenz
Apr 29, 2009·Laboratory Investigation; a Journal of Technical Methods and Pathology·George P ChristophiPaul T Massa
Jun 30, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kumi IzawaToshio Kitamura
Dec 30, 2009·The Journal of Experimental Medicine·Hongkang XiMenno van Lookeren Campagne

❮ Previous
Next ❯

Citations

Apr 21, 2011·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Sang-Min LeeWon-Ha Lee
Jan 15, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Eun-Ju KimWon-Ha Lee
May 4, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sang-Min LeeWon-Ha Lee

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cell Activation

B cell activation is initiated by the ligation of the B cell receptor with antigen and ultimately results in the production of protective antibodies against potentially pathogenic invaders. Here is the latest research.