Immune recognition of gene transfer vectors: focus on adenovirus as a paradigm.

Frontiers in Immunology
Yasser Ali AldhamenAndrea Amalfitano

Abstract

Recombinant Adenovirus (Ad) based vectors have been utilized extensively as a gene transfer platform in multiple pre-clinical and clinical applications. These applications are numerous, and inclusive of both gene therapy and vaccine based approaches to human or animal diseases. The widespread utilization of these vectors in both animal models, as well as numerous human clinical trials (Ad-based vectors surpass all other gene transfer vectors relative to numbers of patients treated, as well as number of clinical trials overall), has shed light on how this virus vector interacts with both the innate and adaptive immune systems. The ability to generate and administer large amounts of this vector likely contributes not only to their ability to allow for highly efficient gene transfer, but also their elicitation of host immune responses to the vector and/or the transgene the vector expresses in vivo. These facts, coupled with utilization of several models that allow for full detection of these responses has predicted several observations made in human trials, an important point as lack of similar capabilities by other vector systems may prevent detection of such responses until only after human trials are initiated. Finally, inducti...Continue Reading

Citations

Jul 3, 2013·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Jin Huk Choi, Maria A Croyle
Nov 10, 2012·Science·Roland W Herzog, David A Ostrov
Oct 20, 2015·Molecular Therapy : the Journal of the American Society of Gene Therapy·Julio Alonso-PadillaAndrew H Baker
Jan 31, 2013·Translational Research : the Journal of Laboratory and Clinical Medicine·Andrea AnnoniMaria Grazia Roncarolo
Sep 19, 2014·Clinical and Vaccine Immunology : CVI·Benjamin J KoestlerChristopher M Waters
Nov 30, 2019·FEBS Letters·Glen Nemerow, Jane Flint
Jan 2, 2019·Journal of Oral Microbiology·Samira ElmanfiUlvi Kahraman Gürsoy
Jan 5, 2021·Human Vaccines & Immunotherapeutics·Firzan NainuHarapan Harapan

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