Immune reconstitution after autologous hematopoietic stem cell transplantation

Mayo Clinic Proceedings
L F PorrataS N Markovic

Abstract

Autologous hematopoietic stem cell transplantation has proved to be an effective treatment for certain hematologic malignancies. However, relapse rates are high during the first year after transplantation. These relapses are attributed to the failure of high-dose chemotherapy to eradicate minimal residual malignant disease. In allogeneic hematopoietic stem cell transplantation, the higher antitumor effects observed compared with those in autologous hematopoietic stem cell transplantation are based on the immunologically mediated graft-vs-tumor effect. Therefore, a better understanding of the mechanisms involved in immune reconstitution after hematopoietic stem cell transplantation may clarify the importance of various components of the recovery of the immune system as they pertain to eradication of residual tumor, as well as uncover possible interventions directed at maximizing this effect. This review focuses on immune reconstitution after autologous hematopoietic stem cell transplantation. Autologous hematopoietic stem cell transplantation is not affected by graft-vs-host disease or immunosuppressive therapy after transplantation to control graft-vs-host disease, providing a direct insight into the mechanisms involved in immu...Continue Reading

References

May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J HackettV Kumar
Oct 12, 1999·Bone Marrow Transplantation·T NordøyA Husebekk

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Citations

May 7, 2013·Bone Marrow Transplantation·A L GarfallE A Stadtmauer
Jul 31, 2012·Clinical & Developmental Immunology·Silke HeidenreichNicolaus Kröger
Jan 24, 2016·Cellular and Molecular Life Sciences : CMLS·Camille GuillereyMark J Smyth
Oct 21, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Miguel-Angel PeralesPhilippe Armand
Apr 4, 2007·Revue neurologique·A Echaniz-Laguna
Aug 19, 2015·Bone Marrow Transplantation·N EpperlaM Hamadani
Nov 26, 2003·Muscle & Nerve·Alejandro A RabinsteinEelco F M Wijdicks
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Dec 1, 2001·Expert Opinion on Biological Therapy·M Hinterberger-Fischer, W Hinterberger
Sep 14, 2004·Leukemia & Lymphoma·Karl S Peggs
Feb 11, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·David Stephen ShulmanLeslie E Lehmann
Jun 11, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Luis F PorrataSvetomir N Markovic
Feb 24, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Miguel-Angel PeralesPhilippe Armand
Feb 29, 2020·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·K HeydariR Alizadeh-Navaei
Nov 13, 2019·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Kosar RaoufinejadMohammad Vaezi

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