PMID: 11334673May 4, 2001Paper

Immune reconstitution after hematopoietic stem cell transplantation: gaining experience without losing naivety

Human Immunology
A Toubert, D Charron

Abstract

In addition to lymphocyte phenotyping and functional assays, new tools are now available to monitor specific aspects of the immune response in the follow-up of hematopoietic stem cell transplantation: reconstitution of T-cell diversity (spectratyping or immunoscope), ex vivo thymic function by measuring "T-cell receptor rearrangement excision DNA circles" and antigen-specific T-cell responses (HLA tetramers). Combining these methods should contribute to improve our current knowledge of how the immune system is reconstituted in different settings of hematopoietic stem cell transplantation and how we could improve this recovery process.

Citations

Mar 2, 2005·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Gameda BarendsePeter Jacobs

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