Immune Recovery after Allogeneic Hematopoietic Stem Cell Transplantation Following Flu-TBI versus TLI-ATG Conditioning

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Muriel HannonFrédéric Baron

Abstract

A conditioning regimen for allogeneic hematopoietic cell transplantation (HCT) combining total lymphoid irradiation (TLI) plus anti-thymocyte globulin (ATG) has been developed to induce graft-versus-tumor effects without graft-versus-host disease (GVHD). We compared immune recovery in 53 patients included in a phase II randomized study comparing nonmyeloablative HCT following either fludarabine plus 2 Gy total body irradiation (TBI arm, n = 28) or 8 Gy TLI plus ATG (TLI arm, n = 25). In comparison with TBI patients, TLI patients had a similarly low 6-month incidence of grade II-IV acute GVHD, a lower incidence of moderate/severe chronic GVHD (P = 0.02), a higher incidence of CMV reactivation (P < 0.001), and a higher incidence of relapse (P = 0.01). While recovery of total CD8(+) T cells was similar in the two groups, with median CD8(+) T-cell counts reaching the normal values 40 to 60 days after allo-HCT, TLI patients had lower percentages of naïve CD8 T cells. Median CD4(+) T-cell counts did not reach the lower limit of normal values the first year after allo-HCT in the two groups. Furthermore, CD4(+) T-cell counts were significantly lower in TLI than in TBI patients the first 6 months after transplantation. Interestingly, wh...Continue Reading

References

Mar 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Frédéric BaronRainer Storb
Jul 26, 2005·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Irina KakhniashviliNeal Flomenberg
Sep 30, 2005·The New England Journal of Medicine·Robert LowskySamuel Strober
Dec 13, 2005·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Alexandra H FilipovichMary E D Flowers
Jan 10, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Gay M CrooksCrystal Mackall
Mar 21, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Michael B MarisRainer Storb
Nov 7, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Frédéric BaronMichael Boeckh
Dec 23, 2008·Immunity·Charles D Surh, Jonathan Sprent
Oct 13, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Ronald E GressWilliam R Drobyski
Jan 1, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R G NadorS Strober
Mar 17, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Peter J PodgornyJan Storek
Jun 29, 2010·European Journal of Immunology·Holbrook E KohrtSamuel Strober
Aug 26, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Joanna M SchaenmanJanice M Brown
Mar 24, 2011·Blood·Werner KrengerGeorg A Holländer
Apr 10, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Giuseppe MessinaUNKNOWN Gruppo Italiano Trapianti di Midollo
Apr 21, 2012·Current Opinion in Hematology·Mark BoschJan Storek
Mar 13, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rainer StorbBrenda M Sandmaier
Dec 10, 2013·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Ying-Jun ChangXiao-Jun Huang
Jan 11, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Sophie ServaisGérard Socie
Feb 28, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alana A Kennedy-NasserCatherine M Bollard
Mar 13, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Jonathan BenjaminRobert Lowsky
Apr 15, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Sumit ChawlaJan Storek
May 21, 2014·Bone Marrow Transplantation·A XhaardG Socié

❮ Previous
Next ❯

Citations

Dec 5, 2015·Expert Review of Hematology·Frédéric BaronArnon Nagler
Apr 26, 2016·Expert Opinion on Investigational Drugs·Sophie ServaisFrédéric Baron
Oct 10, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Amin T TurkiDietrich W Beelen
Sep 15, 2018·Frontiers in Immunology·Grégory EhxFrédéric Baron
Jul 6, 2016·Journal of Hematology & Oncology·Gilles FransoletFrédéric Baron
Nov 20, 2020·Clinical & Translational Immunology·Julika NeumannStephanie Humblet-Baron

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

© 2021 Meta ULC. All rights reserved