Immune regulation and B-cell depletion therapy in patients with primary Sjögren's syndrome

Journal of Autoimmunity
Wayel H AbdulahadHendrika Bootsma

Abstract

Primary Sjögren's syndrome (pSS) is an autoimmune exocrinopathy characterized by chronic inflammation and destruction of the salivary and lacrimal glands. B- and T- lymphocyte infiltrations in the salivary glands with development of germinal center-like structures are characteristic for pSS. Overexpression of soluble factors, such as interferon α (IFNα) and B-cell activating factor (BAFF), are supposed to be important factors in the initiation and continuation of this disorder. The efficacy and success of B-cell depleting therapy in reducing disease activity in pSS patients for about six to nine months supports the notion that B-cells are major key players in disease manifestation of pSS. In addition to B-cells, also Th-cells (mainly Th17) seem to be involved in the pathogenetic process. In this review, we will discuss recent research findings regarding the cytokines IFNα and BAFF as wells as the role of B- and T-cells in pSS. Emphasis will be put on the impact of B-cell depletion therapy as well as on the presumed impact of therapies aimed for targeting BAFF, either as a sole modality or as a combined treatment with B-cell depletion.

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Citations

Aug 27, 2013·Clinical Reviews in Allergy & Immunology·Carlo Selmi
Sep 10, 2013·Journal of Autoimmunity·Pietro Invernizzi
Oct 9, 2012·Rheumatology·Manuel Ramos-Casals
Jan 8, 2014·Current Allergy and Asthma Reports·Katy C LiuRichard M Davis
Sep 26, 2013·Experimental and Molecular Pathology·Babak BabanMahmood S Mozaffari
Aug 26, 2014·Clinical Reviews in Allergy & Immunology·Bin LiuPatrick S C Leung
Aug 13, 2013·Clinical & Developmental Immunology·Yi-fan HuangJun Wang
Jan 17, 2013·Expert Opinion on Therapeutic Targets·Akiko YamadaNaozumi Ishimaru
Jan 4, 2017·The Journal of Rheumatology·Gwenny M VerstappenWayel H Abdulahad
Jun 24, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Liang JinBin Wu
Sep 8, 2018·Arthritis Research & Therapy·Xiuhong WengBo Cheng

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