Immune regulation of neurodevelopment at the mother-foetus interface: the case of autism

Clinical & Translational Immunology
Stefano SotgiuAlessandra Carta

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental disorder defined by deficits in social communication and stereotypical behaviours. ASD's aetiology remains mostly unclear, because of a complex interaction between genetic and environmental factors. Recently, a strong consensus has developed around ASD's immune-mediated pathophysiology, which is the subject of this review. For many years, neuroimmunological studies tried to understand ASD as a prototypical antibody- or cell-mediated disease. Other findings indicated the importance of autoimmune mechanisms such as familial and individual autoimmunity, adaptive immune abnormalities and the influence of infections during gestation. However, recent studies have challenged the idea that autism may be a classical autoimmune disease. Modern neurodevelopmental immunology shows the double-edged nature of many immune effectors, which can be either beneficial or detrimental depending on tissue homeostasis, stressors, neurodevelopmental stage, inherited and de novo gene mutations and other variables. Nowadays, mother-child interactions in the prenatal environment appear to be crucial for the occurrence of ASD. Studies of animal maternal-foetal immune interaction are being fruitfully ca...Continue Reading

References

Dec 1, 1979·Pediatric Research·G B Forbes
Aug 30, 2002·Journal of Autism and Developmental Disorders·Ilan KrauseYehuda Shoenfeld
Nov 17, 2004·Annals of Neurology·Diana L VargasCarlos A Pardo
May 12, 2005·American Journal of Medical Genetics. Part a·J H MilesJ E Farmer
Oct 5, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stephen E P SmithPaul H Patterson
Dec 18, 2007·Cell·Beth StevensBen A Barres
Apr 17, 2008·Nature Reviews. Genetics·Brett S Abrahams, Daniel H Geschwind
Sep 3, 2008·Brain, Behavior, and Immunity·Amanda M EnstromPaul Ashwood
Aug 29, 2009·Journal of Child Neurology·Gehan A MostafaNermeen R Fouad
Apr 24, 2010·Journal of Autism and Developmental Disorders·Hjördis O AtladóttirErik T Parner
Dec 8, 2010·Brain, Behavior, and Immunity·Paula GoinesJudy Van de Water
Apr 21, 2011·Autism Research : Official Journal of the International Society for Autism Research·Allen RosenspireAnthony R Torres
May 27, 2011·Nature·Irina VoineaguDaniel H Geschwind
Jul 23, 2011·Science·Rosa C PaolicelliCornelius T Gross
Oct 26, 2011·Brain Research Bulletin·Joshua A SmithNaren L Banik
Nov 30, 2011·Proceedings of the National Academy of Sciences of the United States of America·Christine Wu NordahlDavid G Amaral
Dec 20, 2011·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Morsi W AbdallahDavid M Hougaard
Jun 13, 2012·Archives of Neurology·Daniel Braunschweig, Judy Van de Water
Jul 28, 2012·Nature Neuroscience·Zaal KokaiaOlle Lindvall
Sep 13, 2012·Nature Reviews. Neuroscience·John F Cryan, Timothy G Dinan
Feb 14, 2013·JAMA Psychiatry·Katsuaki SuzukiNorio Mori
Mar 5, 2013·Journal of Neuroinflammation·Daphne Y S VogelChristine D Dijkstra
Jun 19, 2013·Behavioural Brain Research·Antonio M Persico, Valerio Napolioni
Sep 12, 2013·Journal of Autism and Developmental Disorders·Christy C RossiDavid G Amaral
Sep 5, 2014·Reproduction : the Official Journal of the Society for the Study of Fertility·Nady El HajjThomas Haaf
Oct 15, 2014·Nature Reviews. Neurology·Irene KnueselEric P Prinssen
Nov 19, 2014·Critical Reviews in Immunology·Kevin D CookJason K Whitmire
Feb 15, 2015·Brain, Behavior, and Immunity·Ousseny ZerboLisa A Croen
Jun 16, 2015·Frontiers in Neurology·Yuk Jing LokeJeffrey Mark Craig
Sep 2, 2015·JAMA : the Journal of the American Medical Association·Kristiina TammimiesBridget A Fernandez
Oct 4, 2015·Trends in Immunology·Antoine LouveauJonathan Kipnis
Oct 24, 2015·Biological Psychiatry·Milo CareagaPaul Ashwood
Dec 26, 2015·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Michael J WeiserRobert H Benno
Jan 20, 2016·Nutritional Neuroscience·Junyan FengFeiyong Jia

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

Related Papers

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Amory Meltzer, Judy Van de Water
Methods in Molecular Biology
Milo Careaga, Paul Ashwood
Journal of Leukocyte Biology
Paul AshwoodJudy Van de Water
© 2021 Meta ULC. All rights reserved