Immune-related Adverse Events of Pembrolizumab in a Large Real-world Cohort of Patients With NSCLC With a PD-L1 Expression ≥ 50% and Their Relationship With Clinical Outcomes.

Clinical Lung Cancer
Alessio CortelliniKatia Cannita

Abstract

The role of immune-related adverse events (irAEs), as a surrogate predictor of the efficacy of checkpoint inhibitors, has not yet been described in the setting of first-line, single-agent pembrolizumab for patients with metastatic non-small-cell lung-cancer (NSCLC) with a programmed death-ligand 1 (PD-L1) expression of ≥ 50%. We previously conducted a multicenter retrospective analysis in patients with treatment-naive metastatic NSCLC and a PD-L1 expression of ≥ 50% receiving first-line pembrolizumab. Here, we report the results of the irAE analysis and the potential correlation between irAEs and clinical outcomes. A total of 1010 patients were included in this analysis; after a 6-week landmark selection, 877 (86.8%) patients were included in the efficacy analysis. Any grade irAEs (P < .0001), grade 3/4 irAEs (P = .0025), leading to discontinuation irAEs (P = .0144), multiple-site and single-site irAEs (P < .0001), cutaneous irAEs (P = .0001), endocrine irAEs (P = .0227), pulmonary irAEs (P = .0479), and rheumatologic irAEs (P = .0018) were significantly related to a higher objective response rate. Any grade irAEs (P < .0001), single-site irAEs (P < .0001), multiple-site irAEs (P = .0005), cutaneous irAEs (P = .0042), endocrine...Continue Reading

References

Dec 31, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S ChampiatA Marabelle
Oct 11, 2016·The New England Journal of Medicine·Martin ReckUNKNOWN KEYNOTE-024 Investigators
Aug 26, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dirk SchadendorfMichael A Postow
Sep 25, 2017·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Shunsuke TeraokaKeisuke Tomii
Feb 15, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Julie R BrahmerUNKNOWN National Comprehensive Cancer Network
Apr 7, 2018·Therapeutic Advances in Medical Oncology·Aaron SosaRafael Rosell
Apr 17, 2018·The New England Journal of Medicine·Leena GandhiUNKNOWN KEYNOTE-189 Investigators
Oct 4, 2018·The New England Journal of Medicine·Luis Paz-AresUNKNOWN KEYNOTE-407 Investigators
Jan 9, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Martin ReckJulie R Brahmer
Nov 2, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Filippo G Dall'OlioFrancesco Massari
Nov 16, 2019·Journal of Translational Medicine·Alessio CortelliniPaolo A Ascierto
Feb 29, 2020·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Alessio CortelliniPaolo A Ascierto
Oct 1, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J B A G HaanenUNKNOWN ESMO Guidelines Committee
May 27, 2020·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Olga NigroAlessio Cortellini

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Citations

Aug 9, 2020·Rheumatology International·Guilherme Ferreira Maciel da SilvaFrancisco Airton Castro Rocha
Feb 14, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·David Tak Wai LuiThomas Yau
May 3, 2021·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Sebastiano ButiAlessio Cortellini
Aug 20, 2021·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Vito TotaStéphane Holbrechts

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