Aug 1, 1989

Immune response against Chlamydia trachomatis inoculation in mice--changes in interferon activity, antibody titers and weight of the spleen as parameters of infection

Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases
H KikuchiY Ashihara


We examined the immune response against Chlamydia trachomatis (serovar L2) inoculation in mice by measuring the serum interferon (IFN) level, 2'-5'A synthetase (2-5A(S] activity, antibody titers (IgM, IgG) and the spleen weight as parameters of infection. The interferon activity was detected 6 hrs (400 U/ml) and the activity peaked 12 hrs (450 U/ml) after inoculation, and then gradually decreased thereafter (24 hrs: 12 U/ml, 36 hrs: undetectable). It was found that Chlamydia trachomatis induces IFN as well as bacteria. To monitor the behavior of IFN action after serum IFN was cleared, 2-5A(S) activity in the spleen cell extract was measured. It was found that the activity reached its peak 1 to 2 days after inoculation and then decreased as well as in infectivity of Chlamydia trachomatis. The activity however was almost not detected in sera of mice after inoculation of heat-inactivated Chlamydial organism (56 degrees C, 10 min). This may indicate that intact Chlamydial organisms were required for induction of IFN. IFN induced in mice was stable in pH 2.0 treatment and IFN induced by Newcastle disease virus inhibited growth of Chlamydia trachomatis in L929 cell cultures in a dose-dependent manner. The weight of the spleen gradual...Continue Reading

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Mentioned in this Paper

Infectious Agent Antigen Detection by Immunoassay With Direct Optical Observation; Chlamydia Trachomatis
Chlamydia Infections
Immune Response
Immunofluorescence Assay
Newcastle disease virus
Chlamydial Pneumonia
AS 2
Antibody Titer Measurement
Cell Culture Techniques

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