PMID: 8954146Oct 1, 1996Paper

Immune response against medullary thyroid carcinoma (MTC) induced by parental and/or interleukin-2-secreting MTC cells in a rat model of human familial medullary thyroid carcinoma

Cancer Immunology, Immunotherapy : CII
S LaussonF Treilhou-Lahille

Abstract

The existence of inherited aggressive forms of medullary thyroid carcinoma (MTC), and their resistance to all classical therapies, make it a prime candidate for adoptive immunotherapy. As a prelude to a vaccine for the protection of family members at risk of developing the disease, we investigated the immunological antitumour response provoked by the 6/23 rMTC cell line, compared to that of the same cell engineered to secrete interleukin-2 (rMTC-IL2), in an animal model of familial human MTC, the inbred strain of Wag/Rij rats. The rMTC cells developed a tumour that invaded the whole neck 15 days after orthotopic injection (into the thyroid), while the rMTC-IL2 cells were progressively rejected. Co-injection of rMTC-IL2 with the parental cells induced the rejection of the rMTC transplants. When injected, both tumoral cell types showed a similar positive immunoreaction with anti-MHC class I (major histocompatibility complex class I) antibodies. They both recruited natural killer cells and eosinophils at the site of injection. In addition, CD8+ T lymphocytes infiltrated the rMTC-IL2 cells, and eosinophil recruitment was amplified. Neutrophils, macrophages and CD4+ T lymphocytes were scarce. Our results suggest that the CD8+ T lymp...Continue Reading

Citations

Oct 25, 2000·The Journal of Gene Medicine·M N SolerS Lausson
Feb 23, 2007·Nature Clinical Practice. Endocrinology & Metabolism·Marinella Messina, Bruce G Robinson
May 16, 2014·Endocrine Journal·Padmanaban S SureshRie Tsutsumi
Sep 19, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiu ChenJin-Hai Tang
Sep 13, 2003·Clinical Otolaryngology and Allied Sciences·D S KimJ C Watkinson
Mar 30, 2007·Annales d'endocrinologie·D VezzosiP Caron
Jul 23, 2004·Expert Opinion on Biological Therapy·Luisa BarzonGiorgio Palù

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