Immune Response and Evasion Mechanisms of Plasmodium falciparum Parasites

Journal of Immunology Research
Esmael Besufikad Belachew

Abstract

Malaria causes approximately 212 million cases and 429 thousand deaths annually. Plasmodium falciparum is responsible for the vast majority of deaths (99%) than others. The virulence of P. falciparum is mostly associated with immune response-evading ability. It has different mechanisms to evade both Anopheles mosquito and human host immune responses. Immune-evading mechanisms in mosquito depend mainly on the Pfs47 gene that inhibits Janus kinase-mediated activation. Host complement factor also protects human complement immune attack of extracellular gametes in Anopheles mosquito midgut. In the human host, evasion largely results from antigenic variation, polymorphism, and sequestration. They also induce Kupffer cell apoptosis at the preerythrocytic stage and interfere with phagocytic functions of macrophage by hemozoin in the erythrocytic stage. Lack of major histocompatibility complex-I molecule expression on the surface red blood cells also avoids recognition by CD8+ T cells. Complement proteins could allow for the entry of parasite into the red blood cell. Intracellular survival also assists the escape of malarial parasite. Invading, evading, and immune response mechanisms both in malaria vector and human host are critical t...Continue Reading

References

Aug 2, 2002·The Lancet Infectious Diseases·Lucia Malaguarnera, Salvatore Musumeci
Jan 23, 2003·The Journal of Experimental Medicine·Carlos Ocaña-MorgnerAna Rodriguez
Jun 18, 2004·The Journal of Experimental Biology·Mike A OstaFotis C Kafatos
Nov 4, 2004·Trends in Parasitology·Kirk W Deitsch, Lars Hviid
Feb 8, 2005·The International Journal of Biochemistry & Cell Biology·Hajime HisaedaKunisuke Himeno
Feb 25, 2006·Cell·Alan F Cowman, Brendan S Crabb
Dec 11, 2007·The Journal of Biological Chemistry·Alvaro Molina-CruzCarolina Barillas-Mury
Jun 6, 2009·Current Opinion in Immunology·Sofia Casares, Thomas L Richie
Dec 23, 2009·Developmental and Comparative Immunology·Chris M CirimotichGeorge Dimopoulos
Jan 5, 2012·PLoS Pathogens·Yuemei DongGeorge Dimopoulos
Feb 4, 2012·Trends in Parasitology·D Lys GuilbridePawel Gawlinski
Oct 12, 2012·Seminars in Immunopathology·Photini Sinnis, Fidel Zavala
Aug 22, 2013·Journal of Leukocyte Biology·Masami IkarashiShuhji Seki
Aug 31, 2013·Journal of Innate Immunity·April M ClaytonGeorge Dimopoulos
Nov 2, 2013·Trends in Parasitology·Danielle I StanisicMichael F Good
Jan 30, 2014·Proceedings of the National Academy of Sciences of the United States of America·Qingfeng ChenJianzhu Chen
Mar 22, 2014·PLoS Pathogens·Gavin J Wright, Julian C Rayner
Mar 25, 2014·Annual Review of Immunology·Peter D CromptonSusan K Pierce
Jun 4, 2014·Mediators of Inflammation·Hong ZhengWenyue Xu
Sep 4, 2014·Memórias do Instituto Oswaldo Cruz·Alvaro Molina-Cruz, Carolina Barillas-Mury
Dec 3, 2014·Developmental and Comparative Immunology·Nathan J DennisonGeorge Dimopoulos
Jan 2, 2015·Proceedings of the National Academy of Sciences of the United States of America·Urvashi N RamphulCarolina Barillas-Mury
Mar 6, 2015·Frontiers in Microbiology·Patrick Bertolino, David G Bowen
Jun 17, 2015·Proceedings of the National Academy of Sciences of the United States of America·Ryan C SmithMarcelo Jacobs-Lorena
Nov 27, 2015·Cell Host & Microbe·Veronica Risco-CastilloOlivier Silvie
Feb 10, 2016·Parasites & Vectors·Fabrizio Lombardo, George K Christophides
Mar 26, 2016·Frontiers in Microbiology·Parik KakaniSanjeev Kumar
Sep 9, 2016·Genome Medicine·Sebastian KirchnerAndrew P Waters
Oct 1, 2016·Parasites & Vectors·Mohammad Behram KhanYee-Ling Lau
Nov 2, 2016·Frontiers in Microbiology·Pollyanna S GomesAlexandre Morrot
Nov 22, 2016·Clinical & Translational Immunology·Lauren E HolzWilliam R Heath

❮ Previous
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Citations

Sep 2, 2019·Parasitology Research·Guiling LiuHongyu Han
Oct 15, 2019·Immunological Reviews·Claire LoiseauDenise L Doolan
Jul 12, 2020·Scandinavian Journal of Immunology·Marita Troye-BlombergAnn-Kristin Östlund Farrants
Apr 10, 2019·Infection and Immunity·Festus K AcquahLinda E Amoah
Jul 17, 2019·Journal of Tropical Medicine·Nighina M KhodzhaevaAnatoly K Tokmalaev
Mar 13, 2020·ImmunoTargets and Therapy·Angus Nnamdi OliGordon C Ibeanu
May 7, 2019·Briefings in Functional Genomics·José L Ruiz, Elena Gómez-Díaz
Feb 23, 2020·Frontiers in Immunology·Kehinde Adebayo BabatundePierre-Yves Mantel
Jun 17, 2020·Cellular & Molecular Immunology·Stephen TukwasibweFrancesco Colucci
Apr 6, 2019·Frontiers in Immunology·Janna HeideJulian Schulze Zur Wiesch
Jun 2, 2020·Frontiers in Immunology·Punita SharmaRajnikant Dixit
Feb 4, 2021·Parasitology Research·Sajad RashidiRaúl Manzano-Román
Mar 12, 2021·Frontiers in Cellular and Infection Microbiology·Patricia M SikorskiMichael E Grigg
May 18, 2021·Frontiers in Microbiology·Jingjing CaiWenyue Xu
Aug 17, 2021·Frontiers in Cellular and Infection Microbiology·Monrat Chulanetra, Wanpen Chaicumpa

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