PMID: 6172542Jan 1, 1982Paper

Immune response genes controlling responsiveness to major transplantation antigens. Specific major histocompatibility complex-linked defect for antibody responses to class I alloantigens

The Journal of Experimental Medicine
G ButcherJ C Howard

Abstract

We have identified two major histocompatibility complex (MHC)-linked Ir genes that control the antibody response made by rats against class I major alloantigens. We have named these genes Ir-RT1Aa and Ir-RT1Ac. These Ir genes determine responsiveness of the immunized animal in a typical codominant fashion. There is no evidence so far for trans-complementation between low-responder haplotypes. Detailed studies of Ir-RT1Aa indicate that it controls the antibody response to at least two distinct alloantigenic determinants on RT1Aa molecules. These class I molecules thus behave like hapten-carrier conjugates when the response against the carrier is under Ir gene control. Analysis of the origin of alloantibody-forming cells in tetraparental radiation chimeras indicates that Ir-RT1Aa must control the provision of effective help to B cells. In many respects therefore, the properties of Ir-RT1Aa are broadly similar to those described for Ir genes controlling antibody responses to conventional antigens. The existence of apparently conventional Ir genes controlling the antibody response to major alloantigens strongly suggest that the processing of these transmembrane molecules by host antigen-presenting cells is a prerequisite for immune...Continue Reading

References

Aug 1, 1977·The Journal of Experimental Medicine·M E Dorf, J H Stimpfling
Jun 1, 1975·Journal of Immunological Methods·W F Davidson, C R Parish
Mar 29, 1979·Nature·J C Howard, J R Corvalan
Jul 1, 1976·European Journal of Immunology·G Köhler, C Milstein
Mar 24, 1977·Nature·G W Butcher, J C Howard
Sep 19, 1972·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·J C Howard, J L Gowans
Jan 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·B A AraneoE E Sercarz
Aug 1, 1980·European Journal of Immunology·D Haustein, E Günther
Mar 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·O WeinbergerS J Burakoff

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Citations

Aug 1, 1984·Journal of Reproductive Immunology·D F AntczakL H Remick
Jun 1, 1989·The Journal of Experimental Medicine·E M BoltonJ A Bradley
Dec 1, 1990·The Journal of Experimental Medicine·J A GracieJ A Bradley
Mar 13, 2002·Transplantation·Andreas C PapassavasKenneth I Welsh
Jan 1, 1984·Immunological Reviews·R D Forbes, R D Guttmann
Feb 1, 1989·Immunological Reviews·B J Roser
Aug 1, 1983·Journal of Immunogenetics·T J GillD N Misra

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