Immune response in mouse experimental cholangitis associated with colitis induced by dextran sulfate sodium

Journal of Gastroenterology and Hepatology
Yoshihiro NumataKazuaki Chayama

Abstract

Primary sclerosing cholangitis is frequently complicated by inflammatory bowel disease. Although many colitis models have been reported, little information has been obtained about complicated cholangitis. The aim of the present study was to determine whether hepatobiliary disorders occur in mice experimental colitis, and to clarify the underlying mechanisms. The CD-1 mice were fed standard chow with or without dextran sulfate sodium in the drinking water, followed by histological examination of the liver and colon. Mononuclear cells were isolated from these organs, and cytokine production was assessed. The CD4/CD8 ratio and the population of natural killer T (NKT) cells were analyzed by flow cytometry. Inflammatory cell infiltration and focal necrosis in the liver were found in 33% of treated mice. In treated mice, the CD4/CD8 ratio increased in the liver, whereas no such change was found in the colon. Also an increase of interferon-gamma and a decrease of interleukin-4 production were observed. The NKT cell population showed transient changes in the liver and colon. Hepatobiliary disorders were complicated with experimental colitis in CD-1 mice. Immunological findings indicate a T-helper-1-dominant underlying mechanism, and NK...Continue Reading

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Citations

Sep 28, 2005·Digestive Diseases and Sciences·Yoshihiro NumataKazuaki Chayama
Aug 24, 2005·Inflammatory Bowel Diseases·Norman R HarrisRobert D Specian
Jul 17, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·J Anthony BrandonJ Scott Bryson
May 27, 2009·Seminars in Immunopathology·Jonathan H Aron, Christopher L Bowlus
Jun 28, 2011·Clinics and Research in Hepatology and Gastroenterology·Marion J PollheimerPeter Fickert
Feb 25, 2014·Journal of Hepatology·Peter FickertUNKNOWN International PSC Study Group (IPSCSG)
Oct 22, 2013·Molecular Aspects of Medicine·Marion J PollheimerBruno Stieger
Nov 29, 2011·Best Practice & Research. Clinical Gastroenterology·Marion J PollheimerMichael Trauner
Aug 31, 2014·Clinical Reviews in Allergy & Immunology·Marion J Pollheimer, Peter Fickert
Aug 27, 2016·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G SpazianoB D'Agostino
Jul 27, 2018·Canadian Journal of Gastroenterology & Hepatology·Daniel S SmykDimitrios P Bogdanos

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