Immune response in the bovine mammary gland after intestinal, local, and systemic immunization.

Infection and Immunity
C C ChangN L Norcross

Abstract

The immune response in mammary glands of cattle was measured after intestinal, local, and systemic immunization with T4 bacteriophage. Nonlactating pregnant cows were immunized by infusions into the intestine or mammary gland and by subcutaneous injections in the region of the prescapular or external inguinal lymph nodes. Titers of antibodies of different isotypes were measured in serum and in lacteal secretions by enzyme-linked immunosorbent assay, and numbers of cells producing antibodies of each isotype were determined in lacteal secretions by the Jerne plaque assay. Substantial increases in immunoglobulin G subclass 1 (IgG1) and IgG2 antibody titers were detected in serum and lacteal secretions of animals immunized through an intestinal fistula. IgM and IgA antibody responses were low or undetectable. Low numbers of IgA and IgG1 plaque-forming cells were occasionally detected. It is proposed on the basis of these data that migration of antigen-stimulated IgG lymphoblasts, and perhaps of antigen, to spleen and peripheral lymph nodes may be dominant events after intestinal immunization of ruminants. This is consistent with the predominance of serum-derived IgG antibodies in colostrum and milk. Intramammary infusion of antigen...Continue Reading

References

Mar 1, 1978·The Journal of Clinical Investigation·J MesteckyJ L Babb
Nov 1, 1978·The Journal of Experimental Medicine·A J Husband, J L Gowans
May 1, 1976·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·H FeyF Grolimund
Nov 1, 1977·The Journal of Experimental Medicine·M E RouxM E Lamm
Oct 30, 1975·Nature·R M GoldblumA Sohl-Akerlund
Apr 27, 1971·Biochimica Et Biophysica Acta·J Curtis, F J Bourne
Dec 1, 1971·Journal of Dairy Science·K L SmithH R Conrad
Jul 1, 1971·The Journal of Experimental Medicine·S W Craig, J J Cebra
Oct 1, 1969·The Australian Journal of Experimental Biology and Medical Science·C S Lee, A K Lascelles

❮ Previous
Next ❯

Citations

May 1, 1985·Australian Veterinary Journal·I G Colditz, D L Watson
Jan 19, 2012·Nutrients·Walter L Hurley, Peter K Theil
Jun 1, 1989·Journal of Dairy Science·S C Nickerson
Sep 1, 1987·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·J WiedaK D Hungerer
Jul 1, 1983·Journal of Dairy Science·S C NickersonR A Goldsby
Nov 1, 1985·The Journal of Dairy Research·R F Sheldrake, A J Husband
Jan 1, 1985·Journal of Dairy Science·L J Saif, K L Smith
Aug 1, 1983·Journal of Dairy Science·S P Targowski
Nov 2, 2019·Microbiology and Molecular Biology Reviews : MMBR·Krystyna Dąbrowska, Stephen T Abedon
Mar 15, 2021·Journal of Animal Science·Kasey M SchalichVimal Selvaraj
Oct 1, 1985·Veterinary Immunology and Immunopathology·N Craven, M R Williams
Mar 1, 1983·Veterinary Immunology and Immunopathology·J E Butler

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacteriophage: Phage Therapy

Phage therapy uses bacterial viruses (bacteriophages) to treat bacterial infections and is widely being recognized as an alternative to antibiotics. Here is the latest research.